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刺激家兔舌下神经核中段腹侧区对呼吸节律的影响

董海恒, 刘磊

山东医科大学生理教研室. 山东,济南(250012)

摘要

长串电脉冲刺激家兔舌下神经核中段腹侧区(VMNH)时, 膈肌肌电活动被完全抑制, 而颏舌肌活动明显易化; 在吸气相的中期或后期短串电脉冲刺激VMNH可使吸气切断; 微量注射谷氨酸钠于此区, 膈肌活动也受到抑制。结果表明VMNH对呼吸节律具有调制作用, 这种调制作用可能参与吞咽反射的中枢环节。

关键词： 舌下神经核; 膈肌; 颏舌肌; 呼吸节律; 吞咽中枢

Effects of stimulation of ventromedian area of nucleus hypoglossus on respiratory rhythm in rabbits

Dong Haiheng, Liu Lei

Department of Physiology, Shandong Medical University. Jinan,Shandong

Abstract

The effects of electrical and chemical stimulation of ventromedian area of nucleus hypoglossus (VMNH) on the electrical activities of diaphragm and genioglossus were studied in 25 urethane-anesthetized, vagotomized rabbits. A 6 s train of electrical stimulation caused a complete cessation of diaphragmatic activities and an excitation of genioglossal activities. A 0.1 s train of stimulation of the nucleus during the middle or late inspiratory phase could elicit an inspiratory off-switch effect. Microinjection of L-glutamate into VMNH also produced an inhibition of diaphragmatic activities. The above observations suggest that VMNH activity exerts a regulatory effect on respiratory rhythm, and this effect may be involved in the central mechanism of swallowing reflex.

Key words: Nucleus hypoglossus;Diaphragm;Genioglossus;Respiratory rhythm;Swallowing center

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引用本文：

董海恒, 刘磊. 刺激家兔舌下神经核中段腹侧区对呼吸节律的影响[J]. 生理学报 1994; 46 (3): .

Dong Haiheng, Liu Lei. Effects of stimulation of ventromedian area of nucleus hypoglossus on respiratory rhythm in rabbits. Acta Physiol Sin 1994; 46 (3): (in Chinese with English abstract).