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兔室旁核-脊髓径路对血量扩张引起肾交感神经活动抑制的作用

秦素丽, 林茂樟

大连医学院生理教研室. 辽宁,大连(116023)

摘要

在室旁核(PVN)完好或PVN注射抗坏血酸的双侧窦主动脉去神经的麻醉兔, 血量扩张引起肾交感神经活动(RSNA)抑制均约48%。在红藻氨酸损毁PVN后的3-4h和3-4d, 这种RSNA抑制分别减弱-28.0±4.5%和-25.7±4.1%(P<0.05)同时其抑制时程也显著缩短(P<0.01)。此NA抑制也可被脊髓T_(10)-T_(1 2)节段蛛网膜下腔注射血管升压素能V_(1)受体阻断剂而显著地减弱。在血量扩张时对照组与实验组血压均呈小而短暂升高, 无显著差别。结果表明血量扩张引起的RSNA抑制, 部分是通过迷走传入神经触发PVN-脊髓径路介导 的。图6表1参24

关键词： 室旁核; 室旁核－脊髓径路; 血量扩张; 肾交感神经活动

Role of paraventriculo-spinal pathway in the inhibition of renal sympathetic nerve activity induced by blood volume expansion in rabbits

Qin Suli, Lin Maozhang

Department of Physiology, Dalian Medical College. Dalian,Li aoning

Abstract

In anesthetized and bilateral sinoaortic denervated rabbits with either intact or ascorbic acid injected paraventricular nucleus(PVN), the inhibition of renal sympathetic nerve activity(RSNA) induced by blood volume expansion (VE) all decreased by approximately 48%. However, 3—4h and 3—4d after kainic acid lesion of PVN, the inhibition of RSNA was attenuated respectively to —28.0±4.5% and —25.7±4.1%(P<0.05)with considerably shortened time course (P<0.01). Also such inhibition could be significantly attenuated(P<0.05)by intrathecal injection of vasopressinergic V_(1) receptor antagonist in spinal T_(10)—T_(12)segments. There was no significant difference with the slight and brief increase of mean arterial pressure induced by VE in the control and the experimental group. It was concluded that the inhibition of RSNA induced by VE is partly mediated by a vagal afferent triggered PVN-spinal pathway.

Key words: Paraventricular nucleus;Paraventriculo-spinal pathway;Blood volume expansion;Renal sympathetic nerve activity

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引用本文：

秦素丽, 林茂樟. 兔室旁核-脊髓径路对血量扩张引起肾交感神经活动抑制的作用[J]. 生理学报 1994; 46 (3): .

Qin Suli, Lin Maozhang. Role of paraventriculo-spinal pathway in the inhibition of renal sympathetic nerve activity induced by blood volume expansion in rabbits. Acta Physiol Sin 1994; 46 (3): (in Chinese with English abstract).