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阿片受体激动剂对猪冠状动脉肌条作用的研究

石刚刚, 魏东升, 许绍芬

上海医科大学神经生物学教研室. 上海(200032)

摘要

κ,μ,δ亚型选择性激动剂U-50488H、羟甲基芬太尼(OMF)、吗啡、D-ala-D-Leu-enkephalin(DADLE)以及广谱激动剂依托啡都可引起猪冠状动脉肌条的收缩, 收缩强度以U-50488H>吗啡>依托啡>OMF.DADLE, 上述作用均呈量效关系。图3参11

关键词： 冠状动脉; 阿片受体; 纳洛酮; 氟哌啶醇

Effect of agonists of opioid receptor on coronary arterial strips in porcine

Shi Ganggang, Wei Dongsheng, Xu Shaofen

Department of Neurobiology, Shanghai Medical University. Shanghai

Abstract

Selective agonist of K(U-50488H),u(ohmefentanyl OMF) and B(morphine and DADLE) receptor and wide spectrum agonist of opiod receptor etorphine all produced thew contraction of stripsdose-dependently. The order of the effect was U-50488H>morphine>etorphine >OMF, DADLE. Nalowone did not antagonize but increase the effect, or even produce contraction of the strips by itself. Haloperidol inhibited the contraction of fthe strip produed by U-50488H noncompetitively, also in a dose-dependent manner, probably without involving dopamine mechanism.

Key words: Coronary artery;Opioid receptor;Naloxone;Haloperidol

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引用本文：

石刚刚, 魏东升, 许绍芬. 阿片受体激动剂对猪冠状动脉肌条作用的研究[J]. 生理学报 1994; 46 (2): .

Shi Ganggang, Wei Dongsheng, Xu Shaofen. Effect of agonists of opioid receptor on coronary arterial strips in porcine. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).