过刊浏览

大鼠新生期注射谷氨酸单钠成年后应激时的镇痛效应和血浆皮质酮反应

陈起亮, 李金华, 刘惠慈, 顾风, 印其章

苏州医学院生理学教研室. 江苏,苏州(215007)

摘要

新生期注射谷氨酸单钠(MSG)组大鼠下丘脑弓状核(ARC)的β-内啡肽(β-END)免疫反应细胞减少60.7％, 痛阈和血浆皮质酮的基础值未受影响。在不可躲避的持续电刺激四肢脚底30min后, MSG组动物应激镇痛效应明显降低, 但应激仍可使血浆皮质酮水平明显升高(P<0.01)。提示, ARC的β-END能神经元参与应激镇痛, 而对重体-肾上腺皮质系统应激的血浆皮质酮反应影响不大。

关键词： 谷氨酸单钠; 下丘脑弓状核; #beta#－内啡肽免疫反应细胞; 应激镇痛; 血浆皮质酮

The analgesia effect and plasma corticosterone reaction during stress in adult rats treated neonatally with monosodium glutamate

Chen Qiliang, Li Jinhua, Liu Huici, Gu Feng, Yin Qizhang

Department of Physiology, Suzhou Medical College. Suzhou,Jiangsu

Abstract

In the present investigation, it was found that the number B-END)-immunoreactive neurons of hypothalamic arcuate nucleus (ARC) in MSG-treated rats decreased by 60.7%. No significant differences in the baseline pain threshold and the baseline corticosterone(CS) level were observed between the MSG-treated group and the control group. After electrical foot shock for 30 min, the analgesia effect was decrease significantly in MSA-treated rats, while the CS levels of toth MSA-treated rats and control rats were increased remarked. The results suggest that the B_END neurons of ARC were involved in analgesia, but not in CS reaction during stress.

Key words: Monosodium glutamate;Hypothalamic arcuate nucleus;#beta#-endorphin immunoreactive cells;Stress analgesia;Plasma corticosterone

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

陈起亮, 李金华, 刘惠慈, 顾风, 印其章. 大鼠新生期注射谷氨酸单钠成年后应激时的镇痛效应和血浆皮质酮反应[J]. 生理学报 1994; 46 (2): .

Chen Qiliang, Li Jinhua, Liu Huici, Gu Feng, Yin Qizhang. The analgesia effect and plasma corticosterone reaction during stress in adult rats treated neonatally with monosodium glutamate. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).