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隔区注射AVP和AVP抗血清对家兔温敏神经元放电的影响

杨永录, 陈邦勇

解放军兰州医学高等医专生理教研室. 甘肃,兰州(730020)

摘要

隔区注射精氨酸加压素(AVP)能使家兔视前区-下丘脑前部(PO-AH)热敏神经元放电明显增加, 冷敏神经元放电明显减少; 而隔区注射人工脑脊液对热敏神经元和冷敏神经元的放电均无明显影响。隔区注射AVP抗血清后, PO-AH热敏神经元和冷敏神经元的放电活动出现了与隔区注射AVP相反的结果。隔区注射AVP能提高PO-AH热敏神经元的温度敏感性和降低冷敏神经元的温 度敏感性, 而隔区注射AVP抗血清则反之。结果表明, AVP的退热作用可能是通过兴奋PO-AH的热敏神经元和抑制冷敏神经元的活动, 而致体温降低。

关键词： 精氨酸加压素; 精氨酸加压素抗血清; 单位放电; 隔区; 温度敏感神经元; 温度敏感性

The effect of microinjection of AVP and AVP-antiserum into septal area on discharge activity of temperature-sensitive neurons in PO-AH of rabbits

Yang Yonglu, Chen Bangyong

Department of Physiology, Lanzhou Military Medical College of PLA. Lanzhou, Gansu

Abstract

aRGININE VASOPRESS IN (avp) HAS BEEN SHOWN TO HAVE SIGNICANT EFFECTS ON THERMOREGULATION. AVP-sensitive locus is located in the septal area of the limbic system. The present experiments were undertaken to investigate the effect of microinjecting AVP and AVP-antiserum into the septal area on the firing activity of temperature-sensitive neurons in preoptic-anterior hypothalams(PO-AH) of rabbit. The results were as follows: The firing rate of PO-AH warm-sensitivew and cold-sensitive neurons were respectively increased and decreased by injection AVP while that of temperature-insensitive neurons was unfaffected. Injection of AV=antiserum decreased the firing rate of PO-AH warm-sensitive neurons buyt increased the firing rate of cold-sensitive neurons. Injection of AVP increased the thermosensitivity of PO-AH warm-sensitive neurons and decreased the thermosensitivity of cold-sensitive neurons. The modulation action of AVP on PO-AH temperature-sensitive neurons was discussed.

Key words: Arginine vasopressin;AVP-antiserum;Unit discharge;Septal area;Temperature- tive-neuron;Thermosensitivity

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引用本文：

杨永录, 陈邦勇. 隔区注射AVP和AVP抗血清对家兔温敏神经元放电的影响[J]. 生理学报 1994; 46 (2): .

Yang Yonglu, Chen Bangyong. The effect of microinjection of AVP and AVP-antiserum into septal area on discharge activity of temperature-sensitive neurons in PO-AH of rabbits. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).