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刺激大鼠大脑脚影响脊髓伤害感受性传递的下行途径

王歌昕, 袁斌

西安医科大学神经生理研究室. 陕西,西安(710061)

摘要

刺激大鼠大脑脚(CP)对脊髓背角神经元伤害感受性反应的影响以抑制为主, 部分(30.7％)神经元在抑制作用产生之前先被兴奋。抑制作用主要是通过背索(DF)或背外侧索(DLF)实现的, 在多数神经元是两者共同作用的结果, 其中DLF的作用似乎更为重要。兴奋作用则是通过DF实现的。由于大鼠的皮质脊髓束(CST)位于DF中, 提示大脑皮层不仅可直接通过CST, 而且可经某些脊髓上行结构中继后由DLF下行调控脊髓的伤害感受性传递。

关键词： 大脑皮层; 下行调控; 背髓背角; 伤害感受性传递皮质脊髓束; 背外侧索

Descending pathways mediating the effect of stimulating cerebral peduncle on the spinal nociceptive transmission in the rat

Wang Gexin, Yuan Bin

Research Laboratory of Neurophysiology, Xian Medical University. Xian, Shanxi

Abstract

The descending pathways for the effects of stimulation of cerebral peduncle(CP) on the nociceptive neurons of spinal cord dorsal horn were analyzed by subtotal spinal cord lessions in anesthetized rats. Inhibition was the predominant effect of CP stimulation on the C-fiber elicited nociceptive responses of dorsal hornneurons, in 30.7% of such neurons, the inhibition was preceded by some initial excitation. In most neurons the inhibitory effect was mediated by both dorsal funiculus(DF) and dorsolateral funiculus(DLF), that of DF usually predominated. IT seemed that DLF played a more important role than DF. However, the excitatory effect was mediated by DF alone. Since in the rat the corticospinal tract(CST) is sotuated in the DF, the results suggest that cerebral cortex can modulate spinal nociceptive transmission not only by the CST, but also through a relay in some supraspinal structure(s) sending descending fibers into the DLF.

Key words: Cerebral cortex;Descending control;Spinal cord dorsal horn;Nociceptive transmission;Corticospinal tract

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引用本文：

王歌昕, 袁斌. 刺激大鼠大脑脚影响脊髓伤害感受性传递的下行途径[J]. 生理学报 1994; 46 (2): .

Wang Gexin, Yuan Bin. Descending pathways mediating the effect of stimulating cerebral peduncle on the spinal nociceptive transmission in the rat. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).