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氟卡尼与心肌钠通道相互作用的模拟分析

吴跃进

广东医学院药理教研室

摘要

根据闸门相关受体假说, 应用计算机模拟分析了氟卡尼与心肌钠通道相互作用的动力学特点及其作用的闸门相关受体, 拟在受体水平阐明氟卡尼阻滞钠通道及致心律失常的作用特点及机制。图4参15

关键词： 氟卡尼; 抗心律失常药; 钠通道; 计算机模拟; 闸门相关受体

Modelling and analysis of interactions of flecainide with cardiac sodium channels

Wu Yuejin

Dept. Pharmacol., Guangdong Med. Coll.

Abstract

Model-predicted apparent raes of onset of flecainide blocking were 0.586, 0.128, 0.071, 0.030AP~(-1) respectively at stimulation frequencies of 0.1,0.5, 1.0, 2.0, and 3.3 Hz. The estimated time constant of recovery from block byt flecainide was 17,45 s. Analysis of gate-related receptor showed that the binding and unbinding of flecainide are modulated by activation process.

Key words: Flecainide;Antiarrhythmic agents;Sodium channel;Computer simulation;Gate-relat-ed receptor

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引用本文：

吴跃进. 氟卡尼与心肌钠通道相互作用的模拟分析[J]. 生理学报 1994; 46 (1): .

Wu Yuejin. Modelling and analysis of interactions of flecainide with cardiac sodium channels. Acta Physiol Sin 1994; 46 (1): (in Chinese with English abstract).