过刊浏览

抑郁神经生物学机制研究新进展

高宇博, 李亮萍, 朱心红, 高天明^*

南方医科大学基础医学院神经生物学教研室，广州 510515

摘要

阐明抑郁的神经生物学机制一直是神经科学领域的一个难题，不仅仅是由于抑郁症状的异质性及其病因的多样性，更因其某些症状无法在动物模型上模拟。尽管如此，近年来在抑郁发生机制及药物新靶点的研究上仍取得了一些重要进展。本文对目前抑郁发生机制的主流假说进行了概述和评价，并提出了一些未来可能的发展方向。

关键词： 抑郁; 神经递质; 神经内分泌; 神经免疫; 神经营养因子; 神经再生; 表观遗传学

分类号：R749.4；R338

[Recent progress in neurobiological mechanisms of depression.] [Article in Chinese]

GAO Yu-Bo, LI Liang-Ping, ZHU Xin-Hong, GAO Tian-Ming^*

Department of Neurobiology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China

Abstract

Revealing the neurobiological mechanism of depression has always been a big challenge in the field of neuroscience. Not only are depressive syndromes heterogeneous and their aetiologies diverse, but also some symptoms are impossible to reproduce in animal models. Nevertheless, great progress has been made on the understanding and treatment of depression in recent years. In this review, we focus on key leading hypotheses in the neurobiological mechanism of depression, examine their strengths and weaknesses critically, and also highlight new insights that promise to extend the understanding of depression and its treatment.

Key words: depression; neurotransmitter; neuroendocrine; neuroimmune; neurotrophin; neurogenesis; epigenetics

收稿日期：2012-02-09　　录用日期：2012-05-07

通讯作者：高天明　　E-mail: tgao@fimmu.com

引用本文：

高宇博, 李亮萍, 朱心红, 高天明. 抑郁神经生物学机制研究新进展[J]. 生理学报 2012; 64 (4): 475-480.

GAO Yu-Bo, LI Liang-Ping, ZHU Xin-Hong, GAO Tian-Ming. [Recent progress in neurobiological mechanisms of depression.] [Article in Chinese] . Acta Physiol Sin 2012; 64 (4): 475-480 (in Chinese with English abstract).