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褪黑素抑制低氧引起大鼠大脑皮层氨基酸递质释放

顾靖, 李学君, 孙凤艳

上海医科大学基础医学院神经生物学教研室、医学神经生物学国家重点实验室.上海 200032

摘要

低氧30min时,大鼠大脑皮层脑片孵育液中,氨基酸类神经递质天冬氨酸、谷氨酸、谷氨酰胺、甘氨酸、牛磺酸和#gamma#-氨基丁酸的含量显著增加,其含量分别是正常氧组的240.4%,334.3%,200.6%,210.4%,168.6%和263.9%,与正常氧组比较P<0.01。予以褪黑素可以显著降低兴奋性氨基酸的释放,其中天冬氨酸和谷氨酸的含量分别是低氧组的55.1%和57.0%。

关键词： 褪黑素; 低氧; 脑片; 兴奋性氨基酸

Melatonin decreases the release of amino acid transmitters in hypoxic rat cortical slice

Gu Jing, Li Xuejun, Sun Fengyan

National Key Laboratory of Medical Neurobiology,Department of Neurobiology,Shanghai Medical University.Shanghai 200032

Abstract

The results showed that the contents of amino acids, including aspartate, glutamate, glutamine, glycine, taurine and GABA, in the medium were significantly increased to 240.4%, 334.3%, 200.6%, 210.4%, 168.6% and 263.9%, respectively (P<0.01 vs control) by 30 min hypoxic incubation. Melatonin can significantly reduce the increase of aspartate and glutamate, to 55.1% and 57.0% of the hypoxic group.

Key words: Melatonin;Hypoxia;Brain slice;Excitatory amino acids

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引用本文：

顾靖, 李学君, 孙凤艳. 褪黑素抑制低氧引起大鼠大脑皮层氨基酸递质释放[J]. 生理学报 1999; 51 (4): .

Gu Jing, Li Xuejun, Sun Fengyan. Melatonin decreases the release of amino acid transmitters in hypoxic rat cortical slice. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).