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应激引起血压升高大鼠血管升压素V_(1)受体mRNA水平改变

陆利民, 汪军, 姚泰

上海医科大学生理学教研室.上海 200032；上海医科大学神经生物学国家重点实验室.上海 100032

摘要

慢性应激刺激可引起大鼠不同部位脑组织AVP V_(1)受体合成水平下调,可能导致上述部位组织中AVP V_(1)受体密度降低,而对心脏、肝脏及肾脏组织中的AVP V_(1)受体密度则无显著影响。

关键词： 血管升压素V_(1)受体; 应激; 高血压

Changes in vasopressin V_(1) receptor mRNA level in rats with high blood pressure induced by chronic stress

Lu Limin, Wang Jun, Yao Tai

Department of Physiology,Shanghai Medical University.Shanghai 200032；China

Abstract

Using reverse transcription polymerase chain reaction (RT-PCR) combined with Southern blotting hybridization technique, the AVP V_(1) receptor mRNA was found to be widely distributed in central neuronal system and other tissues of rats, such as cerebral cortex, hypothalamus, medulla, liver and kidney. The receptor mRNA levels in the cortex, hypothalamus and medulla were decreased significantly in chronically stressed rats, as compared with normal controls. But no significant change was observed in tissues of heart, liver and kidney.

Key words: vasopressin V_(1) receptor;Stress;Hypertension

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引用本文：

陆利民, 汪军, 姚泰. 应激引起血压升高大鼠血管升压素V_(1)受体mRNA水平改变[J]. 生理学报 1999; 51 (4): .

Lu Limin, Wang Jun, Yao Tai. Changes in vasopressin V_(1) receptor mRNA level in rats with high blood pressure induced by chronic stress. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).