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血管活性肠肽对清醒大鼠催乳素分泌的影响

朱宝长, 韩菊花, Chiocchio S R

华东师范大学生物系.上海 200062；神经生物研究所.布宜诺斯艾利斯

摘要

在VIP注入后10min时,其外周血液的浓度达到最高值(21.32±2.33)ng/ml,并至少持续30min。在实验的所有动物模型中,VIP均诱导出了显著的催乳素分泌峰(P<0.05),就其提高程度而言,雄性鼠最高(158.4±37.6)ng/ml,未经吸吮刺激的哺乳母鼠最低(31.05±4.42)ng/ml,而经过吸吮刺激的哺乳母鼠则居于两者之间(90.10±36.00)ng/ml。

关键词： 清醒大鼠; 血管活性肠肽; 催乳素; 动物模型

Vasoactive intestinal polypeptide induced prolactin release is model dependent in free-moving rats

Zhu Baochang, Han Juhua, Chiocchio S R

Department of Biology,East China Normal University.Shanghai 200062；Argentina

Abstract

VIP concentration in blood was increased rapidly after the infusion (maximum: 21.32±2.33ng/ml at 10 min and lasting more than 30 min). The concentration of PRL in blood of all the animals tested was increased significantly (P<0.05) after VIP infusion. The increase rate of PRL induced by VIP was higher in male rats (158.04±37.06), but lower in the female (Diestrus: 50.42±16.44, Proestrus: 62/67±21.34) and in Suckling-depended lactating ones (Suckled 90.00±36.00 vs. Separated 31.05±4.42).

Key words: Free moving rats;VIP;Prolactin;Animal models

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引用本文：

朱宝长, 韩菊花, Chiocchio S R. 血管活性肠肽对清醒大鼠催乳素分泌的影响[J]. 生理学报 1999; 51 (3): .

Zhu Baochang, Han Juhua, Chiocchio S R. Vasoactive intestinal polypeptide induced prolactin release is model dependent in free-moving rats. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).