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单羧酸类Cl~(-)通道阻断剂对心室肌CFTR Cl~(-)通道的影响

周士胜, 臧益民

第四军医大学生理学教研室.陕西,西安 710032

摘要

采用全细胞膜片箝与细胞内灌注技术,观察了单羧酸类Cl~(-)通道阻断剂对豚鼠心室肌囊性纤维变性膜透性调节蛋白(CFTR)Cl~(-)电流的影响,结果表明,单羧酸类Cl~(-)通道阻断剂在细胞上有不同的作用位点,该类药物作用效果的差异可能与此有关。

关键词： 异丙肾上腺素; Cl~(-)通道阻断剂; 心室肌; 豚鼠

Effects of monocarboxylic acid derivatives on cardiac ventricular CFTR Cl~(-) channels in guinea pig

Zhou Shesheng, Zang Yimin

Department of Physiology,Fourth Military Medical University.Xi^an 710032,Shaanxi

Abstract

Using the whole-cell recording technique, the effects of monocarboxylic acid derivatives on cystic fibrosis transmembrane conductance regulator (CFTR) Cl~(-)-channel were examined in guinea pig ventricular myocytes. It is concluded that these monocarboxylic acid derivaties have different binding sites in cardiac ventricular myocytes, which might partially account for the varied effects in blocking anion channels.

Key words: Isoproterenol;Chloride channel blocker;Ventricular myocyte;Guinea pig

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引用本文：

周士胜, 臧益民. 单羧酸类Cl~(-)通道阻断剂对心室肌CFTR Cl~(-)通道的影响[J]. 生理学报 1999; 51 (3): .

Zhou Shesheng, Zang Yimin. Effects of monocarboxylic acid derivatives on cardiac ventricular CFTR Cl~(-) channels in guinea pig. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).