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人类胚胎植入过程中的细胞黏附分子

Michiko N. Fukuda, Kazuhiro Sugihara

桑福德/伯纳姆医学研究所癌症中心，拉霍亚，加利福尼亚州，美国； 滨松医科大学妇产科学系，滨松，静冈县，日本

摘要

人类胚胎植入过程不仅受到在进化上保守的机制调节，而且也受到人类一种独有的机制调节。有证据显示，细胞黏附分子L-选择蛋白和trophinin在人类胚胎植入过程扮演独特的角色。在本文中，我们描述了L-选择素和trophinin的黏蛋白糖配体的双重作用，也描述了trophinin相关蛋白bystin和tastin的双重作用。我们随后描述了滋养外胚层细胞和子宫内膜上皮细胞中由trophinin调节的信号转导。本综述也涵盖了钙依粘连蛋白和整合素在人类胚胎植入过程中的作用。

关键词： 胚胎植入; 促性腺激素; 凋亡

分类号：R714.1

Cell adhesion molecules in human embryo implantation

Michiko N. Fukuda, Kazuhiro Sugihara

Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA； Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan

Abstract

The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms, but also by a mechanism unique to humans. Evidence suggests that the cell adhesion molecules, L-selectin and trophinin, play a unique role in human embryo implantation. Here, we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells and endometrial epithelial cells. This review also covers cadherin and integrin in human embryo implantation.

Key words: embryonic implantation; gonadotrophin; apoptosis

收稿日期：2011-12-22　　录用日期：2012-02-22

通讯作者：Michiko N. Fukuda　　E-mail: michiko@burnham.org

引用本文：

Michiko N. Fukuda, Kazuhiro Sugihara. 人类胚胎植入过程中的细胞黏附分子[J]. 生理学报 2012; 64 (3): 247-258.

Michiko N. Fukuda, Kazuhiro Sugihara. Cell adhesion molecules in human embryo implantation. Acta Physiol Sin 2012; 64 (3): 247-258 (in Chinese with English abstract).