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孤束核参与刺激下丘脑室旁核的镇痛作用

蒋星红, 俞光弟, 印其章

苏州医学院神经生物学研究室

摘要

电刺激下丘脑室旁核能产生明显的镇痛效应, 同时放射免疫测定出现脑干加 压素含量升高; 损毁孤束核能取消此效应, 但对基础痛阈无影响; 孤束核内微 量注射加压素拮抗剂[d(CH下 标(2)5Tyr(Me)-AVP]60ng/0.6μl和加压素抗血清0.6 μl都可明显对抗此效应; 直接在孤束核内微量注射加压素60ng/0.6μl, 能模拟 此效应。表明电刺激下丘脑室旁核产生镇痛效应, 其机理之一可能是兴奋了下 丘脑室旁核中加压素能神经元胞体, 后者通过下行投射纤维在 孤束核中释放加 压素, 影响孤束核神经元的活动, 产生镇痛。图7表1参24

关键词： 下丘脑室旁核; 孤束核; 加压素; 镇痛; 加压素抗血清; 加压素拮抗剂; 放射免疫测定

Involvement of solitary tract nucleus in analgesic effect produced by paraventricular nucleus stimulation

Jiang Xinghong, Yu Guangdi, Yin Qizhang

Lab. Neurobiol., Suzhou Med. Coll.

Abstract

Electrical stimulation of the PVN could significantly enhance the pain threshold and increase the content of AVP in brainstem measured by radioimmunoassay. Solitary tract nucleus (STN) lesion could eliminate the analgesic effect induced by PVN stimulation. Intranuclear microinjection of AVP-antagonist and AVP-antiserum into the STN could block the analgesic effect of PVN stimulation. Intranuclear microinjection of AVP into the STN could mimick the analgesic effect similar to that of PVN stimulation. Electrical stimulation of the PVN could produce an analgesic effect. This effect might be mediated by the activation of VP-ergic neurons in PVN and upon releasing VPfrom the descending fibers, the activities of neurons in the STN are influenced.

Key words: Hypothalamic paraventricular nucleus;Solitary tract nucleus;Vasopressin;Analgesis;Vasopressin-antiserum;Vasopressin-antagonist;Radioimmunoassay

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引用本文：

蒋星红, 俞光弟, 印其章. 孤束核参与刺激下丘脑室旁核的镇痛作用[J]. 生理学报 1991; 43 (2): .

Jiang Xinghong, Yu Guangdi, Yin Qizhang. Involvement of solitary tract nucleus in analgesic effect produced by paraventricular nucleus stimulation. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).