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躯体传入冲动抑制中枢性心肌缺血的脊髓机制

朱伟建, 张荣宝

浙江医科大学生理学教研室

摘要

电刺激正中神经(MN)和腓深神经(DPN) 均能抑制或部分抑制下丘脑背内侧核 (DMH)诱发的缺 血性心电ST段偏移, 以刺激MN更为明显。蛛网膜ith吗啡(40μg) 也有此效应。ith纳洛酮(20μg)则可阻断此效应。完整兔在刺激左侧MN或DPN后, 放射免疫技术测得胸2—5(T2—5)节 段两侧中间外侧柱(IML)中亮氨酸脑啡呔(LENK) 量增加。在颈1水平横断背髓以同样参数刺激左侧MN, 同侧胸髓IML中LENK含量明 显增加, 而对侧无改变; 刺激一侧DPN, T2—5的两侧IML中LENK含量均无明显变 化。 表明: 刺激MN与DPN均能抑制DMH诱发的中枢性心肌缺血, 尤以MN作用较明 显。图3 表2参17

关键词： 下丘脑背内侧核; 躯体传入冲动; 亮氨酸脑啡肽; 心肌缺血; 中间外侧栓

Spinal mechanism of the inhibitory effect of somatic input on the cardiac ischemia induced by hypothalamus stimulation

Zhu Weijian, Zhang Rongbao

Dept. Physiol., Zhejiang Med. Univ.

Abstract

Median nerve (MN) or deep peroneal nerve(DPN) stimulation could inhibit completely or partially the deflection of ischemic ECG ST segment due to stimulation of dorsomedial hypothalamic nucleus (DMH). The inhibitory effect of MN stimulation was more marked than that of DPN stimulation. Intrathecal injection (ith) of morphine (40#mu#g) could also have the effect. After ith naloxone (20 #mu#g), this effect was abolished. In intact rabbits, it was demonstrated that L-enkephalin (LENK) immunoreactive material was increased in the left or right intermediolateral cell column (IML) of T2-5 spinal cord after stimulation of left MN or DPN for five minutes. In the Cl transected rabbits, stimulation of MN only increased ipsilateral LENK immunoreactive material content in the thoracic IML, while stimulation of DPN produced no such an effect. These results indicate that stimulation of MN or DPN can inhibit cardiac ischemia induced by DMH stimulation and that the effect of MN stimulation is more potent.

Key words: Dersomedial hypothalamic nucleus;Somatic input;L-enkephalin;Myocardial ischemia;Intermediolateral cell column

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引用本文：

朱伟建, 张荣宝. 躯体传入冲动抑制中枢性心肌缺血的脊髓机制[J]. 生理学报 1991; 43 (2): .

Zhu Weijian, Zhang Rongbao. Spinal mechanism of the inhibitory effect of somatic input on the cardiac ischemia induced by hypothalamus stimulation. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).