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牵拉猫左心房所致的肾效应

孙晓露, 王志安, 何瑞荣

河北医学院基础医学研究所

摘要

迷走神经完整的动物, 牵拉左心室(LAS)导致尿量(UV)、尿钠(U_(NaV)和 尿钾(U_(k)V)(P<0.001)明显增加。切断迷走神经后, LAS仍能使UV、U_(Na)V 有所增加(P<0.01), 在迷走神经完整的猫滴注肝素(10U/min/mg)后, LAS也能引 起UV、U_(Na)V和U_(k)V的增加, 但增值明显低于没有滴注猫。 迷走神经 切除后滴入肝素, 则LAS的肾效应消失(P>0.05)。切断左侧肾神经后, LAS引起 神经完整肾UV和U_(Na)V排出显著增加(P<0.001), 而去神经肾对LAS的效应虽 减弱, 但仍有显著性增值。两侧肾效应的差异, 在统计学上是显著的(P<0.05) 。说明LAS 在麻醉猫中能引起UV、U_(Na)V和U_(K)V明显增加, 这些效应 是神经反射和体液机制共同作用的结果。图3表2参22

关键词： 心房牵拉; 心房容量感受器; 肾神经; 迷走神经; 心房钠尿因子; 肝素

Renal responses to left atrial stretch in the cat

Sun Xiaolu, Wang Zhian, He Ruirong

Inst. Bas. Med., Hebei Med. Coll.

Abstract

Left atrial streth (LAS) resulted in a marked increase in UV, U sub(Na)V and U sub(K)V (all P<0.001) in the intact animals. Although LAS still caused an increase in UV and U sub(Na)V (P<0.01) after vagotomy, the increments were significantly less than those in vagi intact animals (P<0.005). LAS also induced an increase in UV, U sub(Na)V and U sub(K)V (P<0.05) in the vagi intact cats with heparin infusion (10U/min/kg), but the increments were significantly less than those in the cats without heparin (P<0.05). The responses to LAS were abolished by infusion of heparin after vagotomy (P>0.05). Following left renal denervation, theresponses to LAS remained unchanged in the innervated kidney, while those in denervated kidney were attenuated, though still significant. The difference in the response between the innervated and the denervated kidneys was statistically significant (P<0.05). These results indicate that LAS can induce a marked increase in UV, Usub(Na)V and U sub(K)V in anesthetized cats through both neural and humoral mechanisms.

Key words: Atrial stretch;Atrial volume receptor;Renal nerve;Vagus;Atrial natriuretic factor;Heparin

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引用本文：

孙晓露, 王志安, 何瑞荣. 牵拉猫左心房所致的肾效应[J]. 生理学报 1991; 43 (2): .

Sun Xiaolu, Wang Zhian, He Ruirong. Renal responses to left atrial stretch in the cat. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).