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α-人心房钠尿因子对离体豚鼠心肌收缩力和动作电位时程的影响

吴伟建, 夏强

浙江省舟山卫生学校生理学教研组；浙江医科大学生理学教研室

摘要

20nmol/L和40nmol/Lα-人心房钠尿因子(α-hANF)均可明显抑制离体豚鼠乳 头肌收缩幅度(CA)和收缩相上升速率(dA/dt)。40nmol/Lα-hANF作用20 min后, 动作电位时程(APD)缩短明显。提示α-hANF对心肌收缩力和APD具有直接抑制 作用。表1参12

关键词： α-人心房钠尿因子; 收缩力; 动作电位时程; 心肌

Effect of #alpha#-human atrial natriuretic factor on isolated myocardial contractile force and action potential duration in guinea pig

Wu Weijian, Xia Qiang

Sect. Physiol., Zhoushan Hlth Sch., Zhejiang；Dept. Physiol., Zhejiang Med. Univ.

Abstract

At the level of 20 nmol/L and 40 nmol/L #alpha#-hANF, the contraction amplitude and rate of contraction phase decreased to a remarkable extent. And at 40 nmol/L, APDs were shortened significantly 20 nim after #alpha#-hANF. The results suggest that there exists a direct inhibitory effect of #alpha# -hANF on myocardial contractile force and action potential duration.

Key words: #alpha#-human atrial natriuretic factor;Contractile force;Action potential duration;Myocardium

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引用本文：

吴伟建, 夏强. α-人心房钠尿因子对离体豚鼠心肌收缩力和动作电位时程的影响[J]. 生理学报 1991; 43 (2): .

Wu Weijian, Xia Qiang. Effect of #alpha#-human atrial natriuretic factor on isolated myocardial contractile force and action potential duration in guinea pig. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).