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精子相关抗原-6 (SPAG6)在癌症等疾病中的作用研究进展(英文)

李青林^1,2,3, 周鹏展^1,2, 吕志艺^1,2, 刘晗琪^1,2, 刘康¹, 梅杨^2,3,*

¹湖南大学附属湘潭市中心医院，湘潭 411100；²湖南大学生命医学交叉研究院，长沙 410082；³湖大粤港澳大湾区创新研究院(广州增城)，广州 511300

摘要

精子相关抗原6 (sperm-associated antigen 6, SPAG6)蛋白在生殖系统、神经系统、免疫系统和造血系统中发挥关键作用。近年来，SPAG6 在癌症进展和治疗中的作用受到关注。在本综述中，我们系统地总结了SPAG6 分子特征，阐述了其在相关系统中的功能作用及病理生理机制，探讨了其在癌症治疗(尤其是造血系统肿瘤)中的相关性。值得注意的是，临床骨髓增生异常综合征患者中SPAG6 的表达异常升高，且SPAG6 调控MDS-L细胞系的增殖。SPAG6 在不同实验模型中的功能差异尚待阐明，深入揭示其在疾病发生中的具体作用与分子机制，将为开发相关靶向疗法提供依据。

关键词： SPAG6; 发育稳态; 实体瘤; 血液肿瘤; 骨髓增生异常综合征

Sperm-associated antigen 6 (SPAG6): roles in human cancer and other diseases

LI Qing-Lin^1,2,3, ZHOU Peng-Zhan^1,2, Lv Zhi-Yi^1,2, LIU Han-Qi^1,2, LIU Kang¹, MEI Yang^2,3,*

¹The Affiliated Xiangtan Central Hospital of Hunan University, Xiangtan 411100, China；²School of Biomedical Sciences, Hunan University, Changsha 410082, China；³Greater Bay Area Institute for Innovation, Hunan University, Guangzhou 511300, China

Abstract

Emerging evidence indicates that sperm-associated antigen 6 (SPAG6), a protein initially characterized for its role in ciliogenesis and spermatogenesis, plays critical roles not only in the genital system but also in the nervous, immune, and hematopoietic systems. More recently, SPAG6 has been increasingly implicated in cancer progression and treatment. In this review, we systematically summarize the molecular characterization of SPAG6 and delineate its functional roles and pathophysiological mechanisms across multiple organ systems. We also review its therapeutic relevance in cancer management, especially in hematopoietic malignancy. Notably, SPAG6 was found to be aberrantly overexpressed in clinical myelodysplastic syndrome (MDS) patients and promote the proliferation of MDS-L cells. While functional discrepancies of SPAG6 across experimental models warrant further in-depth exploration, elucidating its mechanisms in disease pathogenesis could offer valuable insights for developing targeted therapies for human diseases.

Key words: SPAG6; developmental homeostasis; solid tumor; hematopoietic malignancy; myelodysplastic syndrome

收稿日期：　　录用日期：

通讯作者：梅杨　　E-mail:

DOI: 10.13294/j.aps.2026.0062

引用本文：

李青林, 周鹏展, 吕志艺, 刘晗琪, 刘康, 梅杨. 精子相关抗原-6 (SPAG6)在癌症等疾病中的作用研究进展(英文)[J]. 生理学报 2026; 78 (4): 838-850.

LI Qing-Lin, ZHOU Peng-Zhan, Lv Zhi-Yi, LIU Han-Qi, LIU Kang, MEI Yang. Sperm-associated antigen 6 (SPAG6): roles in human cancer and other diseases. Acta Physiol Sin 2026; 78 (4): 838-850