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泛素化对经典NF-κB信号通路调控机制的研究进展

蒋颖颖^1,2, 陈相洁¹, 龚芳^1,2,*

¹江南大学附属中心医院检验科，无锡 214002；²江南大学无锡医学院，无锡 214122

摘要

NF-κB信号通路是炎症和免疫应答的关键调控通路，其激活可促进炎症因子产生和抑制细胞凋亡。在经典NF-κB信号通路中，泛素化修饰起着重要的调节作用，其中赖氨酸残基48、63 位点(K48、K63)以及甲硫氨酸1 位点(Met1)结合形成的泛素链与NF-κB通路有着更为紧密的联系。本文旨在总结K48、K63 和Met1 连接的泛素化在经典NF-κB信号通路中的作用，对深入了解这些泛素连接类型的作用机制以及揭示其对NF-κB通路的分子调控机制有重要意义，并为炎症和免疫相关疾病的治疗提供新的靶点和策略。

关键词： 泛素化; NF-κB信号通路; K48连接泛素化; K63连接泛素化; Met1连接泛素化

Research progress on the regulatory mechanism of ubiquitination on canonical NF-κB signaling pathway

JIANG Ying-Ying^1,2, CHEN Xiang-Jie¹, GONG Fang^1,2,*

¹Clinical Laboratory, Central Hospital Affiliated to Jiangnan University, Wuxi 214002, China；²Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China

Abstract

NF-κB signaling pathway is a key regulatory pathway of inflammation and immune response, and its activation can promote the production of inflammatory factors and inhibit apoptosis. In the canonical NF-κB signaling pathway, ubiquitin modification plays an important regulatory role, in which the ubiquitin chain formed by lysine residues 48, 63 (K48, K63) and methionine 1 (Met1) is more closely related to the NF-κB pathway. This paper aims to summarize the role of K48, K63 and Met1-linked ubiquitination in the canonical NF-κB signaling pathway, which is of great significance to further understand the mechanism of these ubiquitin-linked types and reveal their molecular regulation mechanism on NF-κB pathway, and provide new targets and strategies for the treatment of inflammatory and immune-related diseases.

Key words: ubiquitination; NF-κB signaling pathway; K48-linked ubiquitination; K63-linked ubiquitination; Met1-linked ubiquitination

收稿日期：　　录用日期：

通讯作者：龚芳　　E-mail:

DOI: 10.13294/j.aps.2026.0043

引用本文：

蒋颖颖, 陈相洁, 龚芳. 泛素化对经典NF-κB信号通路调控机制的研究进展[J]. 生理学报 2026; 78 (3): 551-565.

JIANG Ying-Ying, CHEN Xiang-Jie, GONG Fang. Research progress on the regulatory mechanism of ubiquitination on canonical NF-κB signaling pathway. Acta Physiol Sin 2026; 78 (3): 551-565 (in Chinese with English abstract).