当期文章

自噬调控因子mTOR对肾缺血再灌注损伤的作用及机制

罗茜¹, 杨舒涵², 龚霞^3,*

¹重庆医科大学中医药学院，重庆 400016；²重庆医科大学第一临床学院，重庆 400016；³重庆医科大学基础医学院人体解剖教研室，重庆 400016

摘要

肾缺血再灌注损伤(renal ischemia-reperfusion injury, RIRI)是引起急性肾损伤(acute kidney injury, AKI)的主要原因，同时也是肾移植预后不佳的原因之一，其发病机制主要与氧化应激、自噬和内质网应激等密切相关，其具体作用机制尚不明确。哺乳动物雷帕霉素靶点(mammalian target of rapamycin, mTOR)作为自噬调控因子，通过不同信号通路参与并调节不同阶段RIRI，但其具体作用机制仍需进一步的临床试验研究完善。本文主要通过对RIRI 过程中mTOR相关信号通路的作用及机制进行综述，进一步探讨mTOR作为RIRI新的药物研发和临床治疗靶点的可能性。

关键词： 哺乳动物雷帕霉素靶点; 肾缺血再灌注损伤; 自噬

The role and mechanism of autophagy regulator mTOR in renal ischemia-reperfusion injury

LUO Qian¹, YANG Shu-Han², GONG Xia^3,*

¹College of Chinese Medicine, Chongqing Medical University, Chongqing 400016, China；²First Clinical School, Chongqing Medical University, Chongqing 400016, China；³Department of Human Anatomy, College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China

Abstract

Renal ischemia-reperfusion injury (RIRI) is a major cause of acute kidney injury (AKI) and poor kidney transplantation outcomes. Its pathogenesis is closely related to oxidative stress, autophagy, and endoplasmic reticulum stress, although the specific mechanism is still unclear. The mammalian target of rapamycin (mTOR), as a key regulator of autophagy, plays critical roles at various stages of RIRI through different signaling pathways and contributes to mitigating renal damage. However, the underlying mechanisms require further studies. This review focuses on the role and mechanism of mTOR in RIRI and discusses the potential of mTOR as a therapeutic target.

Key words: mammalian target of rapamycin; renal ischemia-reperfusion injury; autophagy

收稿日期：　　录用日期：

通讯作者：龚霞　　E-mail:

DOI: 10.13294/j.aps.2025.0106

引用本文：

罗茜, 杨舒涵, 龚霞. 自噬调控因子mTOR对肾缺血再灌注损伤的作用及机制[J]. 生理学报 2026; 78 (2): 375-384.

LUO Qian, YANG Shu-Han, GONG Xia. The role and mechanism of autophagy regulator mTOR in renal ischemia-reperfusion injury. Acta Physiol Sin 2026; 78 (2): 375-384 (in Chinese with English abstract).