当期文章

miR-132在抑郁症发病过程中作用的研究进展

孟鼎伦¹, 王青燕¹, 张欣¹, 李舒弘¹, 田春平¹, 贾驰宇¹, 马浩钦², 杨彦玲^1,*

¹延安大学延安医学院，延安 716000；²西安市红会医院，西安 710000

摘要

抑郁症作为临床中高发的精神障碍性疾病，近年来其发病率持续攀升，然而其复杂的病因与发病机制迄今未明。微小RNA (microRNA, miRNA)作为真核生物体内高度保守且广泛分布的关键遗传调控因子，在抑郁症病理进程中扮演重要角色。miR-132 作为中枢神经系统内特异性富集的miRNA分子，通过调控神经元树突棘重塑、突触效能等关键环节，成为抑郁症发病机制研究的热点靶标。现有研究证实，抑郁症患者外周血及动物模型脑组织样本中miR-132 的表达谱呈现显著异常波动，且其表达水平与疾病严重程度、病程进展及治疗响应存在剂量效应关联。因此本文聚焦于脑源性神经营养因子、神经炎症级联反应、神经发生及可塑性等核心环节，深入剖析miR-132 表达变化对抑郁症发生与发展机制的潜在影响，以期为抑郁症治疗领域的深入研究及临床实践提供理论支撑。

关键词： miR-132; 抑郁症; 脑源性神经营养因子; 神经可塑性; 神经炎症

Research progress on the role of miR-132 in the pathogenesis of depression

MENG Ding-Lun¹, WANG Qing-Yan¹, ZHANG Xin¹, LI Shu-Hong¹, TIAN Chun-Ping¹, JIA Chi-Yu¹, MA Hao-Qin², YANG Yan-Ling^1,*

¹Yan'an Medical College of Yan'an University, Yan'an 716000, China；²Xi'an Honghui Hospital, Xi'an 710000, China

Abstract

The prevalence of depression, a common mental disorder in clinical practice, has been continuously increasing in recent years, with its intricate etiology and pathogenesis incompletely understood. MicroRNA (miRNA), a highly conserved and widely distributed genetic regulatory factor in eukaryotic organisms, plays a crucial role in the pathophysiology of depression. miR-132, a miRNA molecule specifically enriched in the central nervous system, has emerged as a significant focus in the study of depression. miR-132 is involved in the pathogenesis by modulating critical processes such as dendritic spine remodeling and synaptic efficacy. Current research confirms that the expression profile of miR-132 in peripheral blood and brain tissue samples from animal models of depression shows significant abnormal fluctuations, and its expression level is dose-dependently associated with disease severity, progression, and treatment response. Therefore, this article focuses on a few key elements, including brain-derived neurotrophic factor, neuroinflammatory cascade reactions, neurogenesis, and plasticity, to comprehensively examine the potential role of miR-132 expression in the onset and progression of depression. This review also aims to provide a theoretical foundation for future in-depth research and clinical applications in the field of depression therapy.

Key words: miR-132; depression; brain-derived neurotrophic factor; neuroplasticity; neuroinflammation

收稿日期：　　录用日期：

通讯作者：杨彦玲　　E-mail:

DOI: 10.13294/j.aps.2025.0074

引用本文：

孟鼎伦, 王青燕, 张欣, 李舒弘, 田春平, 贾驰宇, 马浩钦, 杨彦玲. miR-132在抑郁症发病过程中作用的研究进展[J]. 生理学报 2025; 77 (6): 1109-1122.

MENG Ding-Lun, WANG Qing-Yan, ZHANG Xin, LI Shu-Hong, TIAN Chun-Ping, JIA Chi-Yu, MA Hao-Qin, YANG Yan-Ling. Research progress on the role of miR-132 in the pathogenesis of depression. Acta Physiol Sin 2025; 77 (6): 1109-1122 (in Chinese with English abstract).