当期文章

支链氨基酸在肿瘤发生与发展中的作用及机制

郑任, 胡尘辰, 孙元杰, 胡飞明, 郭琳, 贺元利, 杨舒雅^*

空军军医大学基础医学院免疫学教研室，西安 710032

摘要

支链氨基酸(branched-chain amino acid, BCAA)作为必需氨基酸，近年来在肿瘤代谢领域备受关注。本文综述了BCAA在肿瘤中的代谢特征，探讨了其通过调节信号通路、影响免疫微环境及促进肿瘤转移等机制参与肿瘤发生与发展的过程。研究发现，BCAA代谢异常与多种肿瘤的发生、进展及预后密切相关。通过调控BCAA代谢，有望为肿瘤治疗提供新的靶点和策略。深入研究BCAA在肿瘤中的具体作用机制，将为肿瘤精准治疗提供更多依据。

关键词： 支链氨基酸; 肿瘤; 代谢; 基因表达调控; 饮食

The role and mechanism of branched-chain amino acids in tumorigenesis and progression

ZHENG Ren, HU Chen-Chen, SUN Yuan-Jie, HU Fei-Ming, GUO Lin, HE Yuan-Li, YANG Shu-Ya^*

Department of Immunology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China

Abstract

As essential amino acids, branched-chain amino acids (BCAAs) have attracted much attention in the field of tumor metabolism in recent years. This article reviews the metabolic characteristics of BCAAs in tumors and discusses their involvement in tumorigenesis and development through regulating signaling pathways, affecting the immune microenvironment, and promoting tumor metastasis. Research has shown that abnormal BCAA metabolism is closely related to the occurrence, progression, and prognosis of various tumors. By regulating BCAA metabolism, it is expected to provide new targets and strategies for tumor treatment. Indepth research on the specific mechanisms of BCAAs in tumors will provide more evidence for precision cancer treatment.

Key words: branched-chain amino acid; neoplasms; metabolism; gene expression regulation; diet

收稿日期：　　录用日期：

通讯作者：杨舒雅　　E-mail:

DOI: 10.13294/j.aps.2025.0089

引用本文：

郑任, 胡尘辰, 孙元杰, 胡飞明, 郭琳, 贺元利, 杨舒雅. 支链氨基酸在肿瘤发生与发展中的作用及机制[J]. 生理学报 2025; 77 (6): 1101-1108.

ZHENG Ren, HU Chen-Chen, SUN Yuan-Jie, HU Fei-Ming, GUO Lin, HE Yuan-Li, YANG Shu-Ya. The role and mechanism of branched-chain amino acids in tumorigenesis and progression. Acta Physiol Sin 2025; 77 (6): 1101-1108 (in Chinese with English abstract).