当期文章

靶向内源性神经发生治疗缺血性脑卒中的研究进展

王孟涛¹, 杜海琳², 郝飞³, 郝鹏^1,*

¹首都医科大学基础医学院神经生物学系，北京 100069；²首都医科大学附属北京安贞医院消化内科，北京 100029；³北京航空航天大学医学科学与工程学院，生物材料与神经再生北京市重点实验室，北京 100191

摘要

脑卒中是我国第一位、全球第二位的死亡和致残病因。缺血性脑卒中神经元大量死亡后，由于中枢神经系统再生能力的有限性，严重受限的神经再生导致脑卒中幸存者永久性功能缺失。因此，缺血性脑卒中治疗修复的关键在于通过各种策略实现功能性神经元再生。成年中枢神经系统终生存在内源性神经干细胞，其可以不断生成新的神经元，这为利用内源性神经干细胞修复缺血性脑卒中奠定了内因基础。本文以神经元再生为切入点，综述了缺血性脑卒中后内源性神经发生的改变，重点讨论了通过增强内源性修复机制治疗缺血性脑卒中的最新研究进展，为靶向内源性神经发生治疗缺血性脑卒中提供理论依据。

关键词： 缺血性脑卒中; 内源性神经发生; 新生神经元; 神经营养因子; 康复训练; 物理治疗; 生物活性材料; 细胞转分化

Progress in targeting endogenous neurogenesis for the treatment of ischemic stroke

WANG Meng-Tao¹, DU Hai-Lin², HAO Fei³, HAO Peng^1,*

¹Department of Neurobiology, School of Basic Medicine, Capital Medical University, Beijing 100069, China；²Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China；³Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Engineering Medicine, Beihang University, Beijing 100191, China

Abstract

Stroke is the leading cause of death and disability in China and the second in the world. A large number of neurons died after ischemic stroke. Due to the limited regenerative capacity of central nervous system, severely restricted neuronal regeneration leads to permanent functional impairment. Therefore, the key to the restoration of ischemic stroke is the regeneration of functional neurons through various strategies. Endogenous neural stem cells are present in the adult central nervous system throughout life and are capable of continuously generating new neurons.This is the intrinsic basis for using endogenous neural stem cells to repair ischemic stroke. Focusing on neuronal regeneration, this review summarizes the changes of endogenous neurogenesis after ischemic stroke. In particular, this review discusses new strategies for the treatment of ischemic stroke by enhancing endogenous repair mechanisms, which provides a theoretical basis for targeting endogenous neurogenesis for the treatment of ischemic stroke.

Key words: ischemic stroke; endogenous neurogenesis; newborn neurons; neurotrophic factors; rehabilitation training; physical therapy; bioactive materials; cell transdifferentiation

收稿日期：　　录用日期：

通讯作者：郝鹏　　E-mail:

DOI: 10.13294/j.aps.2025.0098

引用本文：

王孟涛, 杜海琳, 郝飞, 郝鹏. 靶向内源性神经发生治疗缺血性脑卒中的研究进展[J]. 生理学报 2025; 77 (6): 1071-1085.

WANG Meng-Tao, DU Hai-Lin, HAO Fei, HAO Peng. Progress in targeting endogenous neurogenesis for the treatment of ischemic stroke. Acta Physiol Sin 2025; 77 (6): 1071-1085 (in Chinese with English abstract).