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蛋白质乳酸化修饰的生物学功能(英文)

陈嘉琪¹, 何月敬², 郑慧玲¹, 袁源^1,3, 蒋智文⁴, 陈家进¹, 郑馨怡¹, 刘新光¹, 孙雪荣^1,*

¹广东医科大学医学技术学院，广东省医学免疫与分子诊断重点实验室，东莞 523808；²东莞市第八人民医院检验科，东莞 523325；³广东医科大学基础医学院生物技术系，东莞 523808；⁴广东医科大学动物中心实验室，东莞523808

摘要

乳酸化修饰是蛋白质翻译后修饰的一种，由乳酰基团与蛋白质的赖氨酸残基结合形成。这种修饰可改变蛋白质的结构、稳定性和功能，进而调节细胞的新陈代谢、衰老和疾病的发生。本综述将发生乳酸化修饰的蛋白质分为组蛋白和非组蛋白，并分析乳酸化发生时它们的功能作用。乳酸化作用的研究仍处于起步阶段，其调控、功能意义和治疗潜力等诸多方面都有待进一步探索。

关键词： 乳酸化修饰; 翻译后修饰; 生物学功能; 组蛋白; 非组蛋白

The biological functions of protein lactylation

CHEN Jia-Qi¹, HE Yue-Jing², ZHENG Hui-Ling¹, YUAN Yuan^1,3, JIANG Zhi-Wen³, CHEN Jia-Jin¹, ZHENG Xin-Yi¹, LIU Xin-Guang¹, SUN Xue-Rong^1,*

¹Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan 523808, China；²Department of Laboratory Medicine, Dongguan Eighth People's Hospital, Dongguan 523325, China ；³Department of Biotechnology, College of Basic Medical Science, Guangdong Medical University, Dongguan 523808, China

Abstract

Lactylation is one of the post-translational modifications of proteins, a process in which lactyl residues bind to the lysine residues of proteins. This modification can alter the structure, stability, and function of proteins, which in turn regulates cellular metabolism, aging, and the onset of disease. This review classifies proteins with lactylation effects into histones and non-histone proteins and analyzes their functional roles when lactylation occurs. The in-depth exploration of lactylation is still in its infancy, and many aspects of its regulation, functional significance and therapeutic potential need to be further explored.

Key words: lactylation; post-translational modifications; biological function; histones; non-histone proteins

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通讯作者：孙雪荣　　E-mail:

DOI: 10.13294/j.aps.2025.0094

引用本文：

陈嘉琪, 何月敬, 郑慧玲, 袁源, 蒋智文, 陈家进, 郑馨怡, 刘新光, 孙雪荣. 蛋白质乳酸化修饰的生物学功能(英文)[J]. 生理学报 2025; 77 (6): 1035-1046.

CHEN Jia-Qi, HE Yue-Jing, ZHENG Hui-Ling, YUAN Yuan, JIANG Zhi-Wen, CHEN Jia-Jin, ZHENG Xin-Yi, LIU Xin-Guang, SUN Xue-Rong. The biological functions of protein lactylation. Acta Physiol Sin 2025; 77 (6): 1035-1046