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硒蛋白在脂肪组织和肥胖中的作用

赵云飞, 孙宇航, 金太花, 刘悦, 陈阳迪, 许婉, 高倩^*

临沂大学农林科学学院，临沂 276000

摘要

硒蛋白作为硒元素发挥生物学作用的活性形式，在抗氧化、抗肿瘤、免疫、代谢调节、生殖、衰老等多种生理和病理过程中发挥重要调控作用。虽然脂肪组织硒蛋白的含量极易受膳食硒摄入水平的影响，但其与脂肪组织稳态密切相关。本文就近年来有关硒蛋白在脂肪组织生理功能及肥胖病理过程中的调控作用展开综述，以期为开发治疗肥胖及其相关代谢性疾病的潜在药物提供理论基础。

关键词： 硒蛋白; 脂肪生成; 脂质代谢; 肥胖

The role of selenoproteins in adipose tissue and obesity

ZHAO Yun-Fei, SUN Yu-Hang, JIN Tai-Hua, LIU Yue, CHEN Yang-Di, XU Wan, GAO Qian^*

College of Agriculture and Forestry, Linyi University, Linyi 276000, China

Abstract

Selenoproteins, as the active form of selenium, play an important role in various physiological and pathological processes, such as anti-oxidation, anti-tumor, immune response, metabolic regulation, reproduction and aging. Although the expression level of selenoproteins in adipose tissue is significantly influenced by dietary selenium intake, it is closely related to the homeostasis of adipose tissue. In this review, we summarized the role of selenoproteins in the physiological function of adipose tissue and the pathogenesis of obesity in recent years, in order to provide a rationale for developing potential therapeutic agents for the treatment of obesity and related metabolic diseases.

Key words: selenoproteins; adipogenesis; lipid metabolism; obesity

收稿日期：　　录用日期：

通讯作者：高倩　　E-mail:

DOI: 10.13294/j.aps.2025.0082

引用本文：

赵云飞, 孙宇航, 金太花, 刘悦, 陈阳迪, 许婉, 高倩. 硒蛋白在脂肪组织和肥胖中的作用[J]. 生理学报 2025; 77 (5): 939-955.

ZHAO Yun-Fei, SUN Yu-Hang, JIN Tai-Hua, LIU Yue, CHEN Yang-Di, XU Wan, GAO Qian. The role of selenoproteins in adipose tissue and obesity. Acta Physiol Sin 2025; 77 (5): 939-955 (in Chinese with English abstract).