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MAP1家族：探索未知功能的新视角

王晴, 刘梅, 董张及^*

南通大学神经再生重点实验室，神经再生协同创新中心，南通226001

摘要

微管作为细胞骨架的重要组成部分，在细胞分裂、细胞内转运以及维持细胞形态等诸多细胞过程中发挥着至关重要的作用。MAP1家族是一类重要的微管相关蛋白，包含MAP1A、MAP1B和MAP1S三个成员。这些蛋白质广泛参与细胞骨架的动态调节，在中枢神经系统的发育和功能中起着关键作用，尤其在神经元的发育与功能方面表现突出。本文对MAP1家族的研究进展进行了综述，主要聚焦MAP1家族成员的结构与功能，并重点关注它们在神经元发育再生、调控机制以及神经退行性疾病中的作用。

关键词： 微管相关蛋白; MAP1; MAP1A; MAP1B; MAP1S; 神经退行性疾病

The MAP1 family: a new perspective for exploring unknown functions

WANG Qing, LIU Mei, DONG Zhang-Ji^*

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China

Abstract

As an important part of the cytoskeleton, microtubules play a crucial role in many cellular processes, such as cell division, intracellular transport, and maintaining cell morphology. The MAP1 family is an important family of microtubule-associated proteins, which includes three members: MAP1A, MAP1B, and MAP1S. These proteins are widely involved in the dynamic regulation of the cytoskeleton and play a key role in the development and function of the central nervous system, especially in the development and function of neurons. This study reviews the research progress of the MAP1 family, mainly focusing on the structure and function of MAP1 family members, and paying particular attention to their roles in neuronal development and regeneration, regulatory mechanisms, and neurodegenerative diseases.

Key words: microtubule-associated proteins; MAP1; MAP1A; MAP1B; MAP1S; neurodegenerative diseases

收稿日期：　　录用日期：

通讯作者：董张及　　E-mail:

DOI: 10.13294/j.aps.2025.0062

引用本文：

王晴, 刘梅, 董张及. MAP1家族：探索未知功能的新视角[J]. 生理学报 2025; 77 (5): 876-892.

WANG Qing, LIU Mei, DONG Zhang-Ji. The MAP1 family: a new perspective for exploring unknown functions. Acta Physiol Sin 2025; 77 (5): 876-892 (in Chinese with English abstract).