当期文章

热习服对心血管系统的保护作用及其机制研究进展

李国雨, 郭峰, 汪琢, 黄悦^*

沈阳体育学院运动健康学院，沈阳 110102

摘要

热习服通过多层次机制在高温环境中提供心血管保护，然而其作用的全面分子基础仍未明晰。本文系统回顾热习服对血容量、血管功能、心脏结构、能量代谢及抗应激调节的影响，并揭示其在心血管适应性保护中的潜在机制。本文综合了热应激和热习服诱导的多层级反应，包括热习服对热休克蛋白(heat shock proteins, HSPs)、缺氧诱导因子-1 (hypoxiainducible factor 1, HIF-1)及细胞凋亡通路的调控作用。本文还揭示了热习服在不同应激源(如缺氧、热应激)的综合保护效应。本综述为心血管疾病防治和运动医学提供了重要的生理学基础，并指出热习服在多种应激源下的潜在应用前景，支持其作为心血管健康管理和应激防护干预中的有效手段。

关键词： 热习服; 心脏; 心血管保护; 热休克蛋白

Research progress on the protective effects of heat acclimation on the cardiovascular system and its molecular mechanisms

LI Guo-Yu, GUO Feng, WANG Zhuo, HUANG Yue^*

College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China

Abstract

Heat acclimation provides cardiovascular protection in high-temperature environments through multilevel mechanisms; however, the complete molecular basis of its effects remains unclear. In this paper, we systematically review the effects of heat acclimation on blood volume, vascular function, cardiac structure, energy metabolism, and anti-stress regulation, revealing their potential mechanisms in cardiovascular adaptive protection. We also summarizes the multilevel responses induced by heat stress and heat acclimation, including the modulatory effects of heat acclimation on heat shock proteins (HSPs), hypoxia inducible factor 1 (HIF-1), and apoptotic pathways. Additionally, we highlights the comprehensive protective effects of heat acclimation across various stressors (e.g., hypoxia, heat stress). This review provides a significant physiological basis for cardiovascular disease management and sports medicine, emphasizing the potential application of heat acclimation in response to multiple stressors and supporting its role as an effective tool in cardiovascular health management and stress protection interventions.

Key words: heat acclimation; heart; cardiovascular protection; heat shock proteins

收稿日期：　　录用日期：

通讯作者：黄悦　　E-mail:

DOI: 10.13294/j.aps.2025.0050

引用本文：

李国雨, 郭峰, 汪琢, 黄悦. 热习服对心血管系统的保护作用及其机制研究进展[J]. 生理学报 2025; 77 (5): 820-838.

LI Guo-Yu, GUO Feng, WANG Zhuo, HUANG Yue. Research progress on the protective effects of heat acclimation on the cardiovascular system and its molecular mechanisms. Acta Physiol Sin 2025; 77 (5): 820-838 (in Chinese with English abstract).