当期文章

RAAS与时钟基因的相互作用及其在心血管疾病研究中作用的进展

马睿玲¹, 王怡园¹, 寇雨顺¹, 沈路凡¹, 王鸿¹, 张玲娜¹, 田皎¹, 伊琳^1,2,*

¹甘肃中医药大学中西医结合学院，兰州 730000；²甘肃省中医药防治慢性疾病重点实验室，兰州 730000

摘要

肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system, RAAS)在调节血压和维持体液平衡方面具有重要的生理功能，而时钟基因则是保持生物节律和调控代谢的关键因素。RAAS与时钟基因之间存在复杂的交互关系，这种关系可能在多种心血管疾病和代谢性疾病的发生和发展中起着重要作用。尽管已有文献揭示了RAAS与时钟基因之间的相关性，但对二者相互作用的具体机制尚理解不足，且在不同生理和病理状态下的交互模式亟需进一步探讨。本文综述RAAS与时钟基因在心血管疾病中的协同作用，探讨其分子机制、病理生理联系及时辰治疗学的应用及未来研究的潜在方向，以期为相关疾病的预防和治疗提供新的见解。

关键词： 肾素-血管紧张素-醛固酮系统; 时钟基因; 生物节律; 心血管疾病

Research progress of the interaction between RAAS and clock genes in cardiovascular diseases

MA Rui-Ling¹, WANG Yi-Yuan¹, KOU Yu-Shun¹, SHEN Lu-Fan¹, WANG Hong¹, ZHANG Ling-Na¹, TIAN Jiao¹, YI Lin^1,2,*

¹College of Integrated Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China；²Gansu Provincial Key Laboratory of TCM Prevention and Treatment of Chronic Diseases, Lanzhou 730000, China

Abstract

The renin-angiotensin-aldosterone system (RAAS) is crucial for regulating blood pressure and maintaining fluid balance, while clock genes are essential for sustaining biological rhythms and regulating metabolism. There exists a complex interplay between RAAS and clock genes that may significantly contribute to the development of various cardiovascular and metabolic diseases. Although current literature has identified correlations between these two systems, the specific mechanisms of their interaction remain unclear. Moreover, the interaction patterns under different physiological and pathological conditions need further investigation. This review summarizes the synergistic roles of the RAAS and clock genes in cardiovascular diseases, explores their molecular mechanisms and pathophysiological connections, discusses the application of chronotherapy, and highlights potential future research directions, aiming to provide novel insights for the prevention and treatment of related diseases.

Key words: renin-angiotensin-aldosterone system; clock genes; biological rhythms; cardiovascular diseases

收稿日期：　　录用日期：

通讯作者：伊琳　　E-mail:

DOI: 10.13294/j.aps.2025.0064

引用本文：

马睿玲, 王怡园, 寇雨顺, 沈路凡, 王鸿, 张玲娜, 田皎, 伊琳. RAAS与时钟基因的相互作用及其在心血管疾病研究中作用的进展[J]. 生理学报 2025; 77 (4): 669-677.

MA Rui-Ling, WANG Yi-Yuan, KOU Yu-Shun, SHEN Lu-Fan, WANG Hong, ZHANG Ling-Na, TIAN Jiao, YI Lin. Research progress of the interaction between RAAS and clock genes in cardiovascular diseases. Acta Physiol Sin 2025; 77 (4): 669-677 (in Chinese with English abstract).