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非编码RNA调控食管鳞状细胞癌铁死亡的研究进展

王佳敏^1,2,3, 刘盼⁴, 朱蕊⁴, 苏丹^1,4,*

¹中国科学院大学杭州高等研究院分子医学院，杭州 310024；²中国科学院上海药物研究所，上海 201203；³中国科学院大学，北京 100049；⁴浙江省肿瘤医院，中国科学院杭州医学研究所，病理科，杭州 310022

摘要

食管鳞状细胞癌(esophageal squamous cell cancer, ESCC)是一种常见的消化道恶性肿瘤，严重威胁人们的生命健康，其发病率在全球范围内都呈现出不断上升的趋势。越来越多的研究显示，非编码RNA (non-coding RNAs, ncRNAs)，例如微小RNA (microRNAs, miRNAs)、长链非编码RNA (long non-coding RNAs, lncRNAs)和环状RNA (circular RNAs, circRNAs)，在调控铁死亡并参与ESCC的恶性进展中扮演着关键角色。这些ncRNAs通过调节铁代谢和氧化还原平衡，影响ESCC细胞的增殖、凋亡和侵袭能力。如miRNAs可以通过靶向铁死亡相关基因调控细胞的铁积累和氧化应激；lncRNAs可以通过与miRNAs竞争性结合，间接影响铁代谢途径；circRNAs则可能通过海绵效应调控miRNAs的活性。本文从分子机制、调控网络及其在铁死亡过程中的具体作用三个方面，系统综述ncRNAs调控ESCC铁死亡的机制和研究进展。此外，本文也探讨了ncRNAs在ESCC诊断、预后评估及治疗干预中应用的潜力，以期为基于铁死亡的肿瘤治疗干预提供新的思路和靶点。

关键词： 食管鳞状细胞癌; 非编码RNA; 铁死亡; 分子机制

Research progress on the regulation of ferroptosis by non-coding RNAs in esophageal squamous cell cancer

WANG Jia-Min^1,2,3, LIU Pan⁴, ZHU Rui⁴, SU Dan^1,4,*

¹School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China；²Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China；³University of Chinese Academy of Sciences, Beijing 100049, China；⁴Department of Pathology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, China

Abstract

Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy of the digestive tract that poses a significant threat to human health, with an incidence rate that continues to rise globally. Increasing research highlights the crucial role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating ferroptosis and contributing to the malignant progression of ESCC. These ncRNAs influence the proliferation, apoptosis, and invasion capabilities of ESCC cells by modulating iron metabolism and redox balance. miRNAs can regulate cellular iron accumulation and oxidative stress by targeting ferroptosis-related genes; lncRNAs may indirectly affect iron metabolic pathways by competitively binding to miRNAs; circRNAs, through a sponge effect, may regulate the activity of miRNAs. This review systematically summarizes the mechanisms of ncRNAs-mediated regulation of ferroptosis in ESCC, focusing on molecular mechanisms, regulatory networks, and their specific roles in the ferroptosis process. Additionally, the potential of ncRNAs in ESCC diagnosis, prognosis assessment, and therapeutic intervention is discussed, aiming to provide new insights and targets for ferroptosis-based tumor therapy.

Key words: esophageal squamous cell cancer; non-coding RNAs; ferroptosis; molecular mechanisms

收稿日期：　　录用日期：

通讯作者：苏丹　　E-mail:

DOI: 10.13294/j.aps.2024.0078

引用本文：

王佳敏, 刘盼, 朱蕊, 苏丹. 非编码RNA调控食管鳞状细胞癌铁死亡的研究进展[J]. 生理学报 2025; 77 (3): 563-572.

WANG Jia-Min, LIU Pan, ZHU Rui, SU Dan. Research progress on the regulation of ferroptosis by non-coding RNAs in esophageal squamous cell cancer. Acta Physiol Sin 2025; 77 (3): 563-572 (in Chinese with English abstract).