当期文章

线粒体动力学在缺血性脑卒中中的作用机制及治疗策略

郑欣玥¹, 张铭^2,*, 苏凯奇², 丁志敏¹

¹河南中医药大学康复医学院，郑州 450046；²河南中医药大学第一附属医院，郑州 450000

摘要

脑卒中是我国常见的神经系统疾病，有极高的致死、致残率，其中80%为缺血性脑卒中(ischemic stroke, IS)，给个人及社会造成沉重负担。神经元死亡是脑卒中发病的重要因素。研究表明，线粒体动力学作为调节细胞内能量代谢和细胞死亡的关键机制，在IS发病过程中发挥着重要作用。近年来，靶向线粒体动力学成为改善脑卒中后神经功能损伤的新兴治疗手段。本文根据国内外现有研究，综述了近年来在IS线粒体动力学方面的研究进展，从线粒体动力学概述、IS中线粒体动力学的作用及基于线粒体动力学治疗IS的研究进行总结和讨论。本文有助于理解线粒体动力学在IS中的作用机制及有效干预措施，为临床提供靶向线粒体动力学治疗IS的新策略。

关键词： 线粒体动力学; 线粒体分裂、融合; 脑卒中

Mechanisms of mitochondrial dynamics in ischemic stroke and therapeutic strategies

ZHENG Xin-Yue¹, ZHANG Ming^2,*, SU Kai-Qi², DING Zhi-Min¹

¹Rehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou 450046, China；²The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Abstract

As a common neurological disease in China, stroke has an extremely high rate of death and disability, of which 80% is ischemic stroke (IS), causing a serious burden to individuals and society. Neuronal death is an important factor in the pathogenesis of stroke. Studies have shown that mitochondrial dynamics, as a key mechanism regulating intracellular energy metabolism and cell death, plays an important role in the pathogenesis of IS. In recent years, targeting mitochondrial dynamics has become an emerging therapeutic tool to improve neurological impairment after stroke. This paper reviews the research advance in recent years in IS mitochondrial dynamics, summarizing and discussing the overview of mitochondrial dynamics, the role of mitochondrial dynamics in IS, and the studies on mitochondrial dynamics-based treatment of IS. This paper helps to explore the mechanism of the role of mitochondrial dynamics in IS and effective interventions, and provides a theoretical strategy for targeting mitochondrial dynamics to treat IS in the clinic.

Key words: mitochondrial dynamics; mitochondrial fission, fusion; stroke

收稿日期：　　录用日期：

通讯作者：张铭　　E-mail:

DOI: 10.13294/j.aps.2025.0003

引用本文：

郑欣玥, 张铭, 苏凯奇, 丁志敏. 线粒体动力学在缺血性脑卒中中的作用机制及治疗策略[J]. 生理学报 2025; 77 (3): 523-533.

ZHENG Xin-Yue, ZHANG Ming, SU Kai-Qi, DING Zhi-Min. Mechanisms of mitochondrial dynamics in ischemic stroke and therapeutic strategies. Acta Physiol Sin 2025; 77 (3): 523-533 (in Chinese with English abstract).