当期文章

TRIM家族蛋白在调控骨代谢中的作用及机制

杨晶¹, 黄睿奇¹, 徐可¹, 杨绵绵¹, 衣雪洁^1,2,*, 常波³, 姚婷婷¹

¹沈阳体育学院运动健康学院，沈阳 110102；²沈阳体育学院体育社会科学研究中心，沈阳 110102；³珠海科技学院体育科学学院，珠海 519041

摘要

三结构域蛋白(tripartite motif-containing protein, TRIM)家族是一类关键的E3泛素连接酶，近年来在骨代谢调控中的作用受到广泛关注。本文综述了TRIM家族蛋白在骨代谢中的作用及其调控机制，特别是其在骨形成和骨吸收过程中的双重功能，并详细分析了TRIM家族成员调控成骨细胞和破骨细胞活性的信号通路和分子机制。调节TRIM家族蛋白的表达或活性有助于治疗骨质疏松症等骨疾病。本综述重点回顾了TRIM家族成员在骨生理和病理中的分子机制，旨在为开发新型骨疾病治疗策略提供理论依据及科学指导。

关键词： 骨代谢; TRIM家族蛋白; 骨形成; 骨吸收; 骨疾病

Roles and mechanisms of TRIM family proteins in the regulation of bone metabolism

YANG Jing¹, HUANG Rui-Qi¹, XU Ke¹, YANG Mian-Mian¹, YI Xue-Jie^1,2,*, CHANG Bo³, YAO Ting-Ting¹

¹College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China；²Sports Social Science Research Center, Shenyang Sport University, Shenyang 110102, China；³College of Sports Science, Zhuhai College of Science and Technology, Zhuhai 519041, China

Abstract

Tripartite motif-containing (TRIM) family proteins are crucial E3 ubiquitin ligases that have garnered significant attention for their regulatory roles in bone metabolism in recent years. This article reviews the function and regulatory mechanisms of TRIM family proteins in bone metabolism, focusing on their dual roles in bone formation and resorption. It also provides a detailed analysis of signaling pathways and molecular mechanisms by which TRIM family members regulate the activities of osteoblasts and osteoclasts. Research findings suggest that modulating the expression or activity of TRIM family proteins could be beneficial for treating bone diseases such as osteoporosis. This review highlights the molecular mechanisms of TRIM family members in bone physiology and pathology, aiming to provide theoretical basis and scientific guidance for developing novel therapeutic strategies for bone diseases.

Key words: bone metabolism; TRIM family proteins; bone formation; bone resorption; bone diseases

收稿日期：　　录用日期：

通讯作者：衣雪洁　　E-mail:

DOI: 10.13294/j.aps.2025.0027

引用本文：

杨晶, 黄睿奇, 徐可, 杨绵绵, 衣雪洁, 常波, 姚婷婷. TRIM家族蛋白在调控骨代谢中的作用及机制[J]. 生理学报 2025; 77 (3): 472-482.

YANG Jing, HUANG Rui-Qi, XU Ke, YANG Mian-Mian, YI Xue-Jie, CHANG Bo, YAO Ting-Ting. Roles and mechanisms of TRIM family proteins in the regulation of bone metabolism. Acta Physiol Sin 2025; 77 (3): 472-482 (in Chinese with English abstract).