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MEF2C在骨组织发育与代谢中的多效性作用

肖豪杰¹, 黄睿奇^1,2, 林圣傑¹, 李金旸¹, 衣雪洁^1,3, 高海宁^1,*

¹沈阳体育学院运动健康学院，沈阳 110102；²辽宁师范大学体育学院，大连 116029；³沈阳体育学院运动与健康中心，沈阳 110102

摘要

人体内骨的发育过程以及成年后骨量的维持受多种生物因子调控。肌细胞增强因子2C (myocyte enhancer factor 2C,MEF2C)作为诸多调控骨组织发育和平衡因子中的一员，已被证明在骨发育以及骨代谢过程中发挥关键作用。然而关于该因子对骨组织的影响鲜少有系统性的整理与总结。为更好地了解MEF2C对骨组织产生的效应，本文系统梳理了MEF2C在骨发育以及骨代谢中的作用。在骨发育过程中，MEF2C促进神经嵴细胞(neural crest cells, NC)发育为颅面软骨，且直接促进软骨肥大。对于骨代谢，在不同类型的骨细胞中，MEF2C展现出差异化的调控模式，对骨形成过程既有促进也有其他潜在的调控作用，但对破骨细胞目前只确定了其促进作用。鉴于MEF2C对骨组织的复杂效应，本文也讨论了MEF2C对部分骨病的影响，为骨组织的生理学研究及骨性疾病的预防提供理论参考。

关键词： MEF2C; 软骨; 成骨细胞; 破骨细胞; 骨病

The pleiotropic role of MEF2C in bone tissue development and metabolism

XIAO Hao-Jie¹, HUANG Rui-Qi^1,2, LIN Sheng-Jie¹, LI Jin-Yang¹, YI Xue-Jie^1,3, GAO Hai-Ning^1,*

¹Sports Health College of Shenyang Sport University, Shenyang 110102, China；²Institute of Physical Education, Liaoning Normal University, Dalian 116029, China；³Sports and Health Center, Shenyang Sport University, Shenyang 110102, China

Abstract

The development of bone in human body and the maintenance of bone mass in adulthood are regulated by a variety of biological factors. Myocyte enhancer factor 2C (MEF2C), as one of the many factors regulating bone tissue development and balance, has been shown to play a key role in bone development and metabolism. However, there is limited systematic analysis on the effects of MEF2C on bone tissue. This article reviews the role of MEF2C in bone development and metabolism. During bone development, MEF2C promotes the development of neural crest cells (NC) into craniofacial cartilage and directly promotes cartilage hypertrophy. In terms of bone metabolism, MEF2C exhibits a differentiated regulatory model across different types of osteocytes, demonstrating both promoting and other potential regulatory effects on bone formation, with its stimulating effect on osteoclasts being determined. In view of the complex roles of MEF2C in bone tissue, this paper also discusses its effects on some bone diseases, providing valuable insights for the physiological study of bone tissue and strategies for the prevention of bone diseases.

Key words: MEF2C; cartilage; osteoblasts; osteoclasts; bone diseases

收稿日期：　　录用日期：

通讯作者：高海宁　　E-mail:

DOI: 10.13294/j.aps.2025.0024

引用本文：

肖豪杰, 黄睿奇, 林圣傑, 李金旸, 衣雪洁, 高海宁. MEF2C在骨组织发育与代谢中的多效性作用[J]. 生理学报 2025; 77 (2): 374-384.

XIAO Hao-Jie, HUANG Rui-Qi, LIN Sheng-Jie, LI Jin-Yang, YI Xue-Jie, GAO Hai-Ning. The pleiotropic role of MEF2C in bone tissue development and metabolism. Acta Physiol Sin 2025; 77 (2): 374-384 (in Chinese with English abstract).