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多巴胺能系统在神经系统疾病中的研究进展

牛钰琪, 王瑾瑾, 崔文飞, 秦鹏, 高剑峰^*

河南中医药大学医学院，郑州 450046

摘要

神经系统疾病病因复杂，对患者危害大且预后不良。近年来，多巴胺能系统在神经系统疾病中的作用备受关注，其复杂的调控机制和治疗潜力也逐渐被揭示。本文综述了多巴胺能神经元、神经递质多巴胺、多巴胺受体和多巴胺转运蛋白在神经系统疾病(阿尔茨海默病、帕金森病和精神分裂症)中的作用，旨在深入理解疾病机制，以期为神经系统疾病的治疗提供新的思路和策略。

关键词： 多巴胺能系统; 阿尔茨海默病; 帕金森病; 精神分裂症

Research progress of the dopamine system in neurological diseases

NIU Yu-Qi, WANG Jin-Jin, CUI Wen-Fei, QIN Peng, GAO Jian-Feng^*

School of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China

Abstract

The etiology of nervous system diseases is complicated, posing significant harm to patients and often resulting in poor prognoses. In recent years, the role of dopaminergic system in nervous system diseases has attracted much attention, and its complex regulatory mechanism and therapeutic potential have been gradually revealed. This paper reviews the role of dopaminergic neurons, the neurotransmitter dopamine, dopamine receptors and dopamine transporters in neurological diseases (including Alzheimer's disease, Parkinson's disease and schizophrenia), with a view to further elucidating the disease mechanism and providing new insights and strategies for the treatment of neurological diseases.

Key words: dopamine system; Alzheimer''s disease; Parkinson''s disease; schizophrenia

收稿日期：　　录用日期：

通讯作者：高剑峰　　E-mail:

DOI: 10.13294/j.aps.2025.0025

引用本文：

牛钰琪, 王瑾瑾, 崔文飞, 秦鹏, 高剑峰. 多巴胺能系统在神经系统疾病中的研究进展[J]. 生理学报 2025; 77 (2): 309-317.

NIU Yu-Qi, WANG Jin-Jin, CUI Wen-Fei, QIN Peng, GAO Jian-Feng. Research progress of the dopamine system in neurological diseases. Acta Physiol Sin 2025; 77 (2): 309-317 (in Chinese with English abstract).