当期文章

PGC-1α对线粒体功能的调控作用及机制

南淞华¹, 彭超杰¹, 崔应麟^2,*

¹河南中医药大学，郑州 450000；²河南省中医院，郑州 450000

摘要

过氧化物酶体增殖物激活受体γ共激活因子1α (peroxisome proliferator-activated receptor γ coactivator 1 α, PGC-1α)是PGC-1 家族中的核心成员，作为一种转录共激活因子，在多种疾病的发生和发展中发挥关键的调控作用。线粒体是细胞能量代谢的主要场所，对维持细胞生长和功能至关重要，其功能受到多种转录因子和共激活因子的调控。PGC-1α 通过与细胞核内的多个转录因子相互作用，调控线粒体的生物发生、动力学、能量代谢、钙稳态及自噬过程，从而对线粒体功能产生重要影响。本文综述了PGC-1α 的生物学功能及其对线粒体的调控作用和相关机制，为深入理解PGC-1α 在细胞代谢中的作用提供了重要信息。本文也探讨了PGC-1α 在代谢性疾病、心血管疾病和神经退行性疾病中的潜在作用，以期为开发新的治疗策略提供理论依据。

关键词： PGC-1α; 线粒体; 转录因子; 功能紊乱; 调控机制; 治疗作用

The regulatory effect and mechanism of PGC-1α on mitochondrial function

NAN Song-Hua¹, PENG Chao-Jie¹, CUI Ying-Lin^2,*

¹Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China；²Henan Hospital of Traditional Chinese Medicine, Zhengzhou 450000, China

Abstract

Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) is a core member of the PGC-1 family and serves as a transcriptional coactivator, playing a crucial regulatory role in various diseases. Mitochondria, the main site of cellular energy metabolism, are essential for maintaining cell growth and function. Their function is regulated by various transcription factors and coactivators. PGC-1α regulates the biogenesis, dynamics, energy metabolism, calcium homeostasis, and autophagy processes of mitochondria by interacting with multiple nuclear transcription factors, thereby exerting significant effects on mitochondrial function. This review explores the biological functions of PGC-1α and its regulatory effects and related mechanisms on mitochondria, providing important information for our in-depth understanding of the role of PGC-1α in cellular metabolism. The potential role of PGC-1α in metabolic diseases, cardiovascular diseases, and neurodegenerative diseases was also discussed, providing a theoretical basis for the development of new treatment strategies.

Key words: PGC-1α; mitochondrion; transcription factors; functional disorders; regulatory mechanism; therapeutic effect

收稿日期：　　录用日期：

通讯作者：崔应麟　　E-mail:

DOI: 10.13294/j.aps.2025.0036

引用本文：

南淞华, 彭超杰, 崔应麟. PGC-1α对线粒体功能的调控作用及机制[J]. 生理学报 2025; 77 (2): 300-308.

NAN Song-Hua, PENG Chao-Jie, CUI Ying-Lin. The regulatory effect and mechanism of PGC-1α on mitochondrial function. Acta Physiol Sin 2025; 77 (2): 300-308 (in Chinese with English abstract).