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泛凋亡在肿瘤中的研究进展

罗伊凌^1,2, 陈柳燕^1,2, 王耀彬^1,2, 周素芳^1,2,*

¹广西医科大学基础医学院生物化学与分子生物学教研室，南宁 530021；²广西高校生物分子医学研究重点实验室，南宁 530021

摘要

泛凋亡(PANoptosis)是一种由泛凋亡复合体调控的程序性细胞死亡，具有细胞焦亡、凋亡和(或)坏死性凋亡的关键特征。作为最复杂的程序性细胞死亡方式，泛凋亡涉及多种程序性细胞死亡之间的补偿作用，可以通过多种信号通路调节肿瘤细胞的增殖，迁移和侵袭等恶性表型的发生过程，从而影响恶性肿瘤的进展。研究发现泛凋亡在肿瘤进展和治疗中具有抑癌和促癌双重作用，因此深入研究泛凋亡在肿瘤发生、发展中的相关分子机制意义重大。本文综述了细胞凋亡、焦亡和坏死性凋亡的分子机制，总结了泛凋亡及其复合体的激活和调控机制以及泛凋亡在肿瘤发生、发展中的作用，以期为癌症治疗和预后评估提供新的思路。

关键词： 细胞凋亡; 焦亡; 坏死性凋亡; 泛凋亡; 泛凋亡复合体; 肿瘤

Research progress of PANoptosis in cancer

LUO Yi-Ling^1,2, CHEN Liu-Yan^1,2, WANG Yao-Bin^1,2, ZHOU Su-Fang^1,2,*

¹Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangxi Medical University, Nanning 530021, China；²Key Laboratory of Biological Molecular Medicine Research in Guangxi Medical University, Nanning 530021, China

Abstract

PANoptosis is a type of programmed cell death regulated by the PANoptosome with key features of pyroptosis, apoptosis and/or necroptosis. As the most complex programmed cell death, PANoptosis emphasizes the compensatory role among multiple programmed cell deaths, and can regulate malignant phenotypes such as proliferation, migration, and invasion of tumor cells through multiple signaling pathways, thus affecting malignant tumor progression. It has been found that PANoptosis plays a dual role in tumor progression and treatment. Therefore, it is clinically important to understand the molecular mechanisms by which PANoptosis affects tumorigenesis, development and progression. This paper reviews the molecular mechanisms of apoptosis, pyroptosis and necroptosis, and discusses the activation and regulation mechanisms of PANoptosis and PANoptosome as well as the research progress on the role of PANoptosis in tumors, aiming to provide new ideas for cancer treatment and prognostic assessment.

Key words: Apoptosis; pyroptosis; necroptosis; PANoptosis; PANoptosome; tumor

收稿日期：　　录用日期：

通讯作者：周素芳　　E-mail:

DOI: 10.13294/j.aps.2024.0088

引用本文：

罗伊凌, 陈柳燕, 王耀彬, 周素芳. 泛凋亡在肿瘤中的研究进展[J]. 生理学报 2025; 77 (2): 277-288.

LUO Yi-Ling, CHEN Liu-Yan, WANG Yao-Bin, ZHOU Su-Fang. Research progress of PANoptosis in cancer. Acta Physiol Sin 2025; 77 (2): 277-288 (in Chinese with English abstract).