当期文章

NCOA4介导的铁自噬及其相关疾病的研究进展

贾晨¹, 林闳基², 崔芳³, 陆蕊², 张怡婷⁴, 彭志秦⁵, 史敏^1,6,*

¹河北医科大学第二医院检验科，石家庄 050000；²河北医科大学基础医学院，石家庄 050017；³河北医科大学大型科研仪器服务共享平台，石家庄 050017；⁴河北医科大学医学技术学院，石家庄 050031；⁵河北省中医院，石家庄 050011；⁶河北省检验医学重点实验室，石家庄 050000

摘要

核受体共激活因子4 (nuclear receptor co-activator 4, NCOA4)作为一种选择性底物受体，可与胞质铁储存复合物铁蛋白结合，介导铁自噬(ferritinophagy)，释放大量游离铁，调控体内铁代谢平衡，从而参与人体生长、发育、代谢等多种生物过程。近年来研究发现，NCOA4 介导的铁自噬与肝纤维化、肾细胞癌、神经退行性疾病等多种铁代谢相关疾病的发生及发展密切相关。已经确定一些临床药物可调节NCOA4 介导的铁自噬，显著影响疾病的进展和疗效。本文旨在探讨NCOA4 介导的铁自噬在相关疾病中作用的研究进展，以期为临床靶向治疗提供新思路。

关键词： NCOA4; 铁自噬; 疾病; 药物

Research progress on NCOA4-mediated ferritinophagy and related disease

JIA Chen¹, LIN Hong-Ji², CUI Fang³, LU Rui², ZHANG Yi-Ting⁴, PENG Zhi-Qin⁵, SHI Min^1,6,*

¹Department of Clinical Laboratory, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China；²College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China；³Core Facilities and Centers, Hebei Medical University, Shijiazhuang 050017, China；⁴College of Medical Technology, Hebei Medical University, Shijiazhuang 050031, China；⁵Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang 050011, China；⁶Hebei Key Laboratory of Laboratory Medicine, Shijiazhuang 050000, China

Abstract

Nuclear receptor co-activator 4 (NCOA4) acts as a selective cargo receptor that binds to ferritin, a cytoplasmic iron storage complex. By mediating ferritinophagy, NCOA4 regulates iron metabolism and releases free iron in the body, thus playing a crucial role in a variety of biological processes, including growth, development, and metabolism. Recent studies have shown that NCOA4-mediated ferritinophagy is closely associated with the occurrence and development of iron metabolism-related diseases, such as liver fibrosis, renal cell carcinoma, and neurodegenerative diseases. In addition, a number of clinical drugs have been identified to modulate NCOA4-mediated ferritinophagy, significantly affecting disease progression and treatment efficacy. This paper aims to review the current research progress on the role of NCOA4-mediated ferritinophagy in related diseases, in order to provide new ideas for targeted clinical therapy.

Key words: nuclear receptor co-activator 4 (NCOA4); ferritinophagy; disease; drugs

收稿日期：　　录用日期：

通讯作者：史敏　　E-mail:

DOI: 10.13294/j.aps.2025.0017

引用本文：

贾晨, 林闳基, 崔芳, 陆蕊, 张怡婷, 彭志秦, 史敏. NCOA4介导的铁自噬及其相关疾病的研究进展[J]. 生理学报 2025; 77 (1): 194-208.

JIA Chen, LIN Hong-Ji, CUI Fang, LU Rui, ZHANG Yi-Ting, PENG Zhi-Qin, SHI Min. Research progress on NCOA4-mediated ferritinophagy and related disease. Acta Physiol Sin 2025; 77 (1): 194-208 (in Chinese with English abstract).