当期文章

ADAMTS蛋白多糖酶在女性生殖系统中作用的研究进展

李梦蝶^1,2, 孙刚^1,2, 汪旺生^1,2,*

¹上海交通大学医学院附属仁济医院生殖医学中心，上海 200135；²上海市辅助生殖与优生重点实验室，上海 200135

摘要

含Ⅰ型血小板反应蛋白基序的解聚蛋白样金属蛋白酶(a disintegrin and metalloproteinase with thrombospondin-likemotifs, ADAMTS)是一类分泌型的金属蛋白酶，该家族包括19 个成员。根据已知底物谱，ADAMTS被分为5 类：即蛋白多糖酶、前胶原N-肽酶、范威氏因子切割蛋白酶、软骨寡聚基质蛋白酶和其他未知功能蛋白酶。其中，ADAMTS蛋白多糖酶通过降解细胞外基质(extracellular matrix, ECM)中的主要成分透明质蛋白多糖参与ECM的重构和炎症反应，在女性生殖系统的发育和正常功能所需的组织形态发生和发展中起着不可或缺的作用。ADAMTS蛋白多糖酶的功能失调会影响其底物透明质蛋白多糖的结构和功能，破坏ECM微环境的稳态，引起卵泡发育异常、排卵障碍、胎盘形成异常和早产等生殖/妊娠相关疾病。因此研究ADAMTS蛋白多糖酶的作用能够帮助我们更深入地理解女性生殖系统中生理或病理过程的分子机制，为生殖系统疾病的预测和防治提供新的思路。本文综述了ADAMTS 蛋白多糖酶的结构、调控机制及其在女性生殖系统中的作用。

关键词： 含Ⅰ型血小板反应蛋白基序的解聚蛋白样金属蛋白酶; 排卵障碍; 胎盘形成; 早产; 性生殖系统

An update on the role of ADAMTS proteoglycanase in female reproductive system

LI Meng-Die^1,2, SUN Kang^1,2, WANG Wang-Sheng^1,2,*

¹ Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China；² Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China

Abstract

A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) represent a diverse family of secreted metalloproteinases, comprising 19 distinct members categorized into five groups based on their substrate specificity: proteoglycanases, procollagen N-peptidases, von Willebrand factor-cleaving protease, cartilage oligomeric matrix proteases and other proteases. Among these, ADAMTS proteoglycanases predominantly target hyalectans, pivotal components in extracellular matrix (ECM) remodeling and inflammation. Dysfunction of ADAMTS proteoglycanases disrupts the structure and function of hyalectans, thereby perturbing ECM homeostasis, resulting in reproduction disorders, including abnormal follicular development, ovulation dysfunction, impaired implantation, placentation and preterm labor. Hence, investigation of the role of ADAMTS proteoglycanases offers valuable insights into the molecular mechanisms underlying the physiological or pathological processes within the female reproductive system, thereby paving the way for innovative strategies in predicting, preventing and treating reproductive system diseases. This review summarizes the recent research advances in the structure and regulation of ADAMTS proteoglycanases and their role in female reproductive system.

Key words: ADAMTS; ovulation dysfunction; implantation; preterm birth; female reproductive system

收稿日期：　　录用日期：

通讯作者：汪旺生　　E-mail:

DOI: 10.13294/j.aps.2025.0006

引用本文：

李梦蝶, 孙刚, 汪旺生. ADAMTS蛋白多糖酶在女性生殖系统中作用的研究进展[J]. 生理学报 2025; 77 (1): 151-166.

LI Meng-Die, SUN Kang, WANG Wang-Sheng. An update on the role of ADAMTS proteoglycanase in female reproductive system. Acta Physiol Sin 2025; 77 (1): 151-166 (in Chinese with English abstract).