当期文章

铁死亡在心脏疾病中的作用及机制研究进展

崔语桐¹, 祝欣欣¹, 张琦¹, 曲爱娟^1,2,3,*

¹首都医科大学基础医学院生理学与病理生理学系，北京100069；²重塑相关心血管疾病教育部重点实验室，北京 100069；³代谢紊乱相关疾病北京市重点实验室，北京100069

摘要

心血管疾病是我国不可忽视的主要死亡原因，其发病率和死亡率仍在不断攀升。同时，铁死亡在许多心脏疾病中发挥重大作用。铁死亡是一种独特的铁依赖性形式的程序性细胞死亡。铁离子代谢失调、氧化还原障碍和脂质过氧化是铁死亡的三大经典机制。最新研究发现铁死亡还包括诸多新机制：辅酶Q10、铁蛋白自噬、脂质自噬、线粒体代谢障碍、核因子E2 相关因子2 (nuclear factor erythroid 2-related factor 2, NRF2)调控等。本文综述了铁死亡相关机制研究进展，分析了其在心力衰竭、心肌缺血/再灌注损伤、糖尿病心肌病、阿霉素的心肌毒性、脓毒症性心肌病和心律失常等心脏疾病中的作用机制，并探讨了铁死亡抑制剂/诱导剂在心血管疾病中的作用，提示铁死亡很可能成为心血管疾病的重要干预靶点。

关键词： 心脏疾病; 铁死亡; 铁死亡抑制剂

Research progress on the role and mechanism of ferroptosis in heart diseases

CUI Yu-Tong¹, ZHU Xin-Xin¹, ZHANG Qi¹, QU Ai-Juan^1,2,3,*

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China；²Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China；³Beijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases, Beijing 100069, Chin

Abstract

Cardiovascular disease remains the leading cause of death in China, with its morbidity and mortality continue to rise. Ferroptosis, a unique form of iron-dependent cell death, plays a major role in many heart diseases. The classical mechanisms of ferroptosis include iron metabolism disorder, oxidative antioxidant imbalance and lipid peroxidation. Recent studies have found many additional mechanisms of ferroptosis, such as coenzyme Q10, ferritinophagy, lipid autophagy, mitochondrial metabolism disorder, and the regulation by nuclear factor erythroid 2-related factor 2 (NRF2). This article reviews recent advances in understanding the mechanisms of ferroptosis and its role in heart failure, myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, myocardial toxicity of doxorubicin, septic cardiomyopathy, and arrhythmia. Furthermore, we discuss the potential of ferroptosis inhibitors/inducers as therapeutic targets for heart diseases, suggesting that ferroptosis may be an important intervention target of heart diseases.

Key words: heart diseases; ferroptosis; ferroptosis inhibitors

收稿日期：　　录用日期：

通讯作者：曲爱娟　　E-mail:

DOI: 10.13294/j.aps.2025.0010

引用本文：

崔语桐, 祝欣欣, 张琦, 曲爱娟. 铁死亡在心脏疾病中的作用及机制研究进展[J]. 生理学报 2025; 77 (1): 75-84.

CUI Yu-Tong, ZHU Xin-Xin, ZHANG Qi, QU Ai-Juan. Research progress on the role and mechanism of ferroptosis in heart diseases. Acta Physiol Sin 2025; 77 (1): 75-84 (in Chinese with English abstract).