当期文章

脂肪组织感觉神经支配与代谢性疾病

郭一帆^1,2, 陈佩杰^1,2, 肖卫华^1,2,*

¹上海体育大学运动健康学院，上海 200438；²上海市人类运动能力开发与保障重点实验室，上海 200438

摘要

脂肪组织的稳态调节对于机体维持能量代谢平衡至关重要，周围神经系统在这一过程中发挥着关键角色。以往的相关研究主要关注于交感神经及其释放的去甲肾上腺素，然而近年来，对于脂肪神经支配和功能的关注已经集中到脂肪感觉神经领域。研究表明，外部刺激能够通过瞬时受体电位香草素亚型1 (transient receptor potential vanilloid-1, TRPV1)、脂肪因子和脂肪酸的途径激活脂肪感觉神经，从而向大脑传递信号。新兴的脂肪神经成像和组织去神经等技术显示，感觉神经在脂肪组织的糖脂代谢、产热功能和血管调节中具有关键作用。本文综述了脂肪组织感觉神经调节和功能研究的最新进展，深入讨论了代谢性疾病对脂肪感觉神经的影响，并对当前存在的问题进行了探讨，希望有助于全面理解脂肪组织神经调控的机制，为未来研究提供新的方向。

关键词： 脂肪组织; 感觉神经; 代谢性疾病

Sensory neural innervation of adipose tissue in metabolic disorders

GUO Yi-Fan^1,2, CHEN Pei-Ji^1,2, XIAO Wei-Hua^1,2,*

¹School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China；²Shanghai Key Lab of Human Performance, Shanghai 200438, China

Abstract

The regulation of adipose tissue homeostasis is essential for maintaining energy and metabolism balance in the body. The peripheral nervous system plays a crucial role in this process. Previous related research primarily focused on the sympathetic nervous system and its release of norepinephrine, while recent attention has shifted to the field of adipose sensory nerves. Studies demonstrate that external stimuli can activate adipose sensory nerves through pathways involving transient receptor potential vanilloid-1 (TRPV1), adipokines, and fatty acids, thereby transmitting signals to the brain. Emerging techniques, such as adipose nerve imaging and denervation of tissues, have revealed the critical role of sensory nerves in the glucose and lipid metabolism, thermogenic function, and vascular regulation of adipose tissue. This article comprehensively reviews the latest research on the regulation and function of sensory nerves in adipose tissue, with a focus on the impact of metabolic diseases on adipose sensory nerves. This review discusses current issues and prospects on the mechanisms behind neural regulation in adipose tissue, hoping to contribute to a comprehensive understanding and providing directions for future research.

Key words: adipose tissue; sensory nerves; metabolic diseases

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通讯作者：肖卫华　　E-mail:

引用本文：

郭一帆, 陈佩杰, 肖卫华. 脂肪组织感觉神经支配与代谢性疾病[J]. 生理学报 2024; 76 (5): 841-848.

GUO Yi-Fan, CHEN Pei-Ji, XIAO Wei-Hua. Sensory neural innervation of adipose tissue in metabolic disorders. Acta Physiol Sin 2024; 76 (5): 841-848 (in Chinese with English abstract).