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色氨酸-犬尿氨酸途径在神经病理性疼痛中的作用

吴子晗¹, 尤浩军^1,2, 雷静^1,2,*

¹延安大学感觉与运动转化医学研究中心，延安 716000；²延安市运动康复医学重点实验室，延安 716000

摘要

犬尿氨酸途径(kynurenine pathway, KP)是膳食中色氨酸的主要代谢途径。已有研究表明KP在多种疾病的发生机制中起关键作用。现已证明KP代谢酶[例如吲哚胺2，3-双加氧酶(indoleamine 2,3-dioxygenase, IDO)、犬尿氨酸单加氧酶(kynurenine monooxygenase, KMO)等]参与各种疼痛，尤其是神经病理性疼痛的发生和发展。本文综述了KP、代谢物与代谢酶的作用以及KP在神经病理性疼痛中的镇痛作用和机制，为KP在神经病理性疼痛的基础研究和临床治疗方面的应用提供参考。

关键词： 色氨酸-犬尿氨酸途径; 犬尿酸; 喹啉酸; 神经病理性疼痛

The role of the tryptophan-kynurenine pathway in neuropathic pain

WU Zi-Han¹, YOU Hao-Jun^1,2, LEI Jing^1,2,*

¹Center for Translational Medicine Research on Sensory-Motor Diseases, Yan’an University, Yan’an 716000, China；²Key Laboratory of Yan’an Sports Rehabilitation Medicine, Yan’an 716000, China

Abstract

The kynurenine pathway (KP) is the main metabolic pathway of tryptophan in the diet. Existing research has shown that KP plays a key role in the pathogenesis of various diseases. It has been demonstrated that kynurenine metabolic enzymes, such as indoleamine 2,3-dioxygenase (IDO) and kynurenine monooxygenase (KMO), are involved in various types of pain, particularly the occurrence and development of neuropathic pain. This article reviewed the role of KP, metabolites and enzymes, as well as the analgesic effects and mechanisms of KP in neuropathic pain, providing reference for the application of KP in the basic research and clinical treatment of neuropathic pain.

Key words: tryptophan-kynurenine pathway; kynurenine; quinolinic acid; neuropathic pain

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通讯作者：雷静　　E-mail:

引用本文：

吴子晗, 尤浩军, 雷静. 色氨酸-犬尿氨酸途径在神经病理性疼痛中的作用[J]. 生理学报 2024; 76 (5): 818-826.

WU Zi-Han, YOU Hao-Jun, LEI Jing. The role of the tryptophan-kynurenine pathway in neuropathic pain. Acta Physiol Sin 2024; 76 (5): 818-826 (in Chinese with English abstract).