ISSN 0371-0874, CN 31-1352/Q

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m6A甲基化修饰是神经病理性疼痛的潜在生物靶点

张玉婷, 张励才*

徐州医科大学江苏省麻醉学重点实验室,徐州 221004

摘要

N6-甲基腺嘌呤(N6-methyladenosine, m6A)是真核生物中最常见的RNA修饰类型,通过甲基转移酶、去甲基化酶和m6A结合蛋白的动态可逆性调控影响细胞内的RNA代谢,控制相关病理生理过程的基因表达。近年来,m6A甲基化修饰参与神经病理性疼痛的研究成为热点,一些新的认识不断涌现,m6A甲基化修饰成为治疗神经病理性疼痛的潜在生物靶点。本文就m6A甲基化修饰在神经病理性疼痛中的作用和调控机制进行综述,以期为神经病理性疼痛的药物开发和治疗提供新的启示。


关键词: N6-甲基腺嘌呤; 甲基转移酶; 去甲基化酶; m6A结合蛋白; 神经病理性疼痛

m6A RNA methylation is a potential biological target for neuropathic pain

ZHANG Yu-Ting, ZHANG Li-Cai*

Jiangsu Provincial Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, China

Abstract

N6-methyladenosine (m6A) is the most common type of RNA modification in eukaryotes, which affects intracellular RNA metabolism and controls gene expression of related pathophysiological processes through dynamic reversible regulation of methyltransferases, demethylases and m6A-binding proteins. In recent years, the involvement of m6A methylation in the study of neuropathic pain has become a hot topic, some new understandings have been emerging, and m6A methylation has become a potential biological target for the treatment of neuropathic pain. Therefore, this article reviews the role and regulation of m6A methylation in neuropathic pain, in order to provide new enlightenment for the drug development and treatment of neuropathic pain.


Key words: N6-methyladenosine; methyltransferases; demethylases; m6A-binding protein; neuropathic pain

收稿日期:  录用日期:

通讯作者:张励才  E-mail:

引用本文:

张玉婷, 张励才. m6A甲基化修饰是神经病理性疼痛的潜在生物靶点[J]. 生理学报 2024; 76 (5): 809-817.

ZHANG Yu-Ting, ZHANG Li-Cai. m6A RNA methylation is a potential biological target for neuropathic pain. Acta Physiol Sin 2024; 76 (5): 809-817 (in Chinese with English abstract).