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m⁶A甲基化修饰是神经病理性疼痛的潜在生物靶点

张玉婷, 张励才^*

徐州医科大学江苏省麻醉学重点实验室，徐州 221004

摘要

N6-甲基腺嘌呤(N6-methyladenosine, m⁶A)是真核生物中最常见的RNA修饰类型，通过甲基转移酶、去甲基化酶和m6A结合蛋白的动态可逆性调控影响细胞内的RNA代谢，控制相关病理生理过程的基因表达。近年来，m⁶A甲基化修饰参与神经病理性疼痛的研究成为热点，一些新的认识不断涌现，m⁶A甲基化修饰成为治疗神经病理性疼痛的潜在生物靶点。本文就m⁶A甲基化修饰在神经病理性疼痛中的作用和调控机制进行综述，以期为神经病理性疼痛的药物开发和治疗提供新的启示。

关键词： N6-甲基腺嘌呤; 甲基转移酶; 去甲基化酶; m6A结合蛋白; 神经病理性疼痛

m⁶A RNA methylation is a potential biological target for neuropathic pain

ZHANG Yu-Ting, ZHANG Li-Cai^*

Jiangsu Provincial Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, China

Abstract

N6-methyladenosine (m⁶A) is the most common type of RNA modification in eukaryotes, which affects intracellular RNA metabolism and controls gene expression of related pathophysiological processes through dynamic reversible regulation of methyltransferases, demethylases and m⁶A-binding proteins. In recent years, the involvement of m6A methylation in the study of neuropathic pain has become a hot topic, some new understandings have been emerging, and m⁶A methylation has become a potential biological target for the treatment of neuropathic pain. Therefore, this article reviews the role and regulation of m⁶A methylation in neuropathic pain, in order to provide new enlightenment for the drug development and treatment of neuropathic pain.

Key words: N6-methyladenosine; methyltransferases; demethylases; m6A-binding protein; neuropathic pain

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通讯作者：张励才　　E-mail:

引用本文：

张玉婷, 张励才. m⁶A甲基化修饰是神经病理性疼痛的潜在生物靶点[J]. 生理学报 2024; 76 (5): 809-817.

ZHANG Yu-Ting, ZHANG Li-Cai. m⁶A RNA methylation is a potential biological target for neuropathic pain. Acta Physiol Sin 2024; 76 (5): 809-817 (in Chinese with English abstract).