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MicroRNA在脊髓损伤中的研究进展

魏栋敏¹, 方蕊², 邓智中¹, 白心悦¹, 朱晶惠¹, 翟天宇¹, 张灿¹, 高建忠³, 苏丹¹, 杨彦玲¹, 赵琳^1,*

¹延安大学医学院，延安 716000；²德州市第二人民医院医学影像科，德州 254300；³榆林市第一人民医院神经外科，榆林 719000

摘要

脊髓损伤(spinal cord injury, SCI)是一种严重的中枢神经系统疾病，致残率和死亡率较高，具有复杂的病理生理机制。微小RNA (microRNA, miRNA)作为一种非编码RNA，在SCI中发挥重要作用。miRNA参与SCI后的炎症反应、氧化应激、轴突再生、细胞凋亡等的调控，并与长链非编码 RNA (long non-coding RNA, lncRNA)、环状 RNA (circular RNA, circRNA)相互作用调节SCI的病理生理过程。本文归纳了SCI后miRNA的表达变化，综述了miRNA在SCI中的靶向机制及miRNA靶向药物的研究现状，为SCI的基础和临床研究提供新靶点和新视野。

关键词： 脊髓损伤; microRNA; 炎症反应; 氧化应激; 轴突再生; 细胞凋亡; 自噬; 铁死亡

Research progress of microRNA in spinal cord injury

WEI Dong-Min¹, FANG Rui², DENG Zhi-Zhong¹, BAI Xin-Yue¹, ZHU Jing-Hui¹, ZHAI Tian-Yu¹, ZHANG Can¹, GAO Jian-Zhong³, SU Dan¹, YANG Yan-Ling¹, ZHAO Lin^1,*

¹Medical College of Yan’an University, Yan’an 716000, China；²Department of Imaging, Dezhou Second People’s Hospital, Dezhou 254300, China；³Neurosurgery Department of Yulin First People’s Hospital, Yulin 719000, China

Abstract

Spinal cord injury (SCI) is a serious central nervous system disease with high disability and mortality rates and complex pathophysiologic mechanisms. MicroRNA (miRNA), as a kind of non-coding RNA, plays an important role in SCI. miRNA is involved in the regulation of inflammatory response, oxidative stress, axonal regeneration, and apoptosis after SCI, and interacts with long non-coding RNA (lncRNA) and circular RNA (circRNA) to regulate the pathophysiological process of SCI. This paper summarizes the changes in miRNA expression after SCI, and reviews the targeting mechanism of miRNA in SCI and the current research status of miRNA-targeted drugs to provide new targets and new horizons for basic and clinical research on SCI.

Key words: spinal cord injury; microRNA; inflammatory response; oxidative stress; axonal regeneration; apoptosis; autophagy; ferroptosis

收稿日期：　　录用日期：

通讯作者：赵琳　　E-mail:

DOI: 10.13294/j.aps.2024.0026

引用本文：

魏栋敏, 方蕊, 邓智中, 白心悦, 朱晶惠, 翟天宇, 张灿, 高建忠, 苏丹, 杨彦玲, 赵琳. MicroRNA在脊髓损伤中的研究进展[J]. 生理学报 2024; 76 (3): 394-406.

WEI Dong-Min, FANG Rui, DENG Zhi-Zhong, BAI Xin-Yue, ZHU Jing-Hui, ZHAI Tian-Yu, ZHANG Can, GAO Jian-Zhong, SU Dan, YANG Yan-Ling, ZHAO Lin. Research progress of microRNA in spinal cord injury. Acta Physiol Sin 2024; 76 (3): 394-406