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NLRP3炎症小体在糖尿病及运动中作用的研究进展

温瑞明¹, 吕红艳^1,2, 常波¹, 衣雪洁^1,3,*

¹沈阳体育学院运动健康学院，沈阳 110102；²辽宁师范大学体育学院，大连 116029；³沈阳体育学院体育社会科学研究中心，沈阳 110102

摘要

慢性非感染性炎症反应已经被证明是糖尿病发生和发展过程中的重要标志，伴有大量炎症因子的产生，从而加重疾病进程。运动作为诸多无创性抑制炎症反应的重要干预措施，在改善糖尿病症状中有着极为重要的作用。核苷酸结合寡聚化结构域样受体蛋白3 (NOD-like receptor protein 3, NLRP3)炎症小体作为炎症反应的调控因子，通常可以引发多种炎症级联反应和细胞焦亡，与葡萄糖的摄取和血脂异常密切相关。运动可以延缓糖尿病的发病进程，以往的研究聚焦于NLRP3炎症小体对糖尿病的作用，但并未系统阐明运动对该作用的影响。因此，本文综述运动干预通过介导NLRP3炎症小体改善糖尿病症状的研究进展，为运动防治糖尿病提供新的理论基础。

关键词： NLRP3炎症小体; 糖尿病; 运动

Role of NLRP3 inflammasome in diabetes mellitus and exercise intervention

WEN Rui-Ming¹, LYU Hong-Yan^1,2, CHANG Bo¹, YI Xue-Jie^1,3,*

¹School of Sports and Human Sciences, Shenyang Sport University, Shenyang 110102, China；²School of Physical Education, Liaoning Normal University, Dalian 116029, China；³Sports Social Science Research Center, Shenyang Sport University, Shenyang 110102, China

Abstract

Chronic inflammatory reaction has been established as an important sign of the occurrence and development of diabetes mellitus (DM), accompanied by the production of a large number of inflammatory factors, thus aggravating the disease progression. As an important non-invasive intervention measure to inhibit inflammation, exercise plays a very important role in the amelioration of DM. NOD-like receptor protein 3 (NLRP3) inflammasome, a regulatory factor of inflammatory response, can induce a variety of inflammatory cascades and cell death, which are closely related to glucose uptake and dyslipidemia regulation. The development of DM can be postponed with exercise. Previous studies have reported the effects of NLRP3 inflammasome on DM, but the crucial role of exercise in this process remains unclear. Therefore, this paper reviews the research progress on the improving effects of exercise intervention on the symptoms of DM by mediating NLRP3 inflammasome, providing a novel theoretical foundation for understanding the prevention and treatment of DM through exercise. 

Key words: NLRP3 inflammasome; diabetes mellitus; exercise

收稿日期：　　录用日期：

通讯作者：衣雪洁　　E-mail: yixuejie8387@163.com

DOI: 10.13294/j.aps.2023.0053

引用本文：

温瑞明, 吕红艳, 常波, 衣雪洁. NLRP3炎症小体在糖尿病及运动中作用的研究进展[J]. 生理学报 2023; 75 (6): 788-798.

WEN Rui-Ming, LYU Hong-Yan, CHANG Bo, YI Xue-Jie. Role of NLRP3 inflammasome in diabetes mellitus and exercise intervention. Acta Physiol Sin 2023; 75 (6): 788-798 (in Chinese with English abstract).