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高原环境影响慢性阻塞性肺疾病及治疗药物的研究进展

曾祥海^1,2,3, 索南格勒⁴, 黄琴¹, 李玉^1,2,3, 张晓静¹, 李文斌^1,2,3, 王荣^1,2,3,*

¹联勤保障部队第九四〇医院药剂科，兰州 730050；²宁夏医科大学药学院，银川 750004；³甘肃省高原药学行业技术中心，兰州 730050；⁴青海省玉树州人民医院内科，玉树 815099

摘要

高原环境具有低氧、低气压、低温、强紫外线等特点，慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是一种可预防和可治疗的慢性疾病。高原环境影响COPD患病率、临床指标和死亡率。治疗COPD的茶碱类药物治疗窗窄，高原环境会影响药物的药代动力学过程。本文对高原和平原COPD患病率、死亡率、临床指标与临床症状差异进行归纳和总结，为发现高原地区COPD的危险因素提供依据，并分析高原低氧环境对COPD药物药代动力学的影响，为高原COPD的预防与合理用药提供参考。

关键词： 高原; 慢性阻塞性肺疾病; 合理用药

The research progress of high altitude environment-associated chronic obstructive pulmonary disease and therapeutic drugs

ZENG Xiang-Hai^1,2,3, SUONAN Ge-Le⁴, HUANG Qin¹, LI Yu^1,2,3, ZHANG Xiao-Jing¹, LI Wen-Bin^1,2,3, WANG Rong^1,2,3,*

¹Department of Pharmacy, the 940th Hospital of the Joint Logistic Support Force, Lanzhou 730050, China；²School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China；³Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China；⁴Department of Internal Medicine, Qinghai Yushu People’s Hospital, Yushu 815099, China

Abstract

The plateau environment is characterized by low oxygen, low air pressure, low temperature, and strong ultraviolet rays, etc. Chronic obstructive pulmonary disease (COPD) is a preventable and treatable chronic lung disease. High altitude environment increases COPD prevalence, clinical manifestation and mortality. The therapeutic window of theophylline drugs for COPD is narrow, and the high altitude environment has an influence on the pharmacokinetics of the drugs. This review summarizes the differences in the prevalence, mortality, clinical manifestation and clinical symptoms of COPD in the plateau and plain, providing a basis for identifying the risk factors of COPD in the plateau areas. The effects of plateau hypoxic environment on the pharmacokinetics of COPD drugs were also discussed. It can provide a rationale for more effective prevention and treatment of COPD at high altitude.

Key words: high altitude; chronic obstructive pulmonary disease; rational drug use

收稿日期：　　录用日期：

通讯作者：王荣　　E-mail: wangrong-69@163.com

DOI: 10.13294/j.aps.2023.0066

引用本文：

曾祥海, 索南格勒, 黄琴, 李玉, 张晓静, 李文斌, 王荣. 高原环境影响慢性阻塞性肺疾病及治疗药物的研究进展[J]. 生理学报 2023; 75 (5): 691-702.

ZENG Xiang-Hai, SUONAN Ge-Le, HUANG Qin, LI Yu, ZHANG Xiao-Jing, LI Wen-Bin, WANG Rong. The research progress of high altitude environment-associated chronic obstructive pulmonary disease and therapeutic drugs. Acta Physiol Sin 2023; 75 (5): 691-702