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Kalirin-7在运动改善神经退行性疾病中的作用研究进展

余梦苑, 田振军^*

陕西师范大学体育学院暨运动生物学研究所，西安 710119

摘要

中枢神经系统鸟嘌呤核苷酸交换因子Kalirin-7 (Kal-7)是突触可塑性的关键因子，在大脑中发挥重要调控作用。突触功能异常可导致学习记忆等认知功能减弱，并伴随Kal-7异常表达，进而诱发多种神经退行性疾病。运动可上调相关脑区Kal-7表达，预防或减轻脑部神经退行性疾病。本文通过对Kal-7与神经退行性疾病及其运动干预研究进展的文献梳理，归纳Kal-7在运动改善神经退行性疾病中的作用及其可能机制，为运动防控神经退行性疾病的基础与临床研究提供新视野和新靶点。

关键词： Kalirin-7 (Kal-7); 神经退行性疾病; 突触可塑性; 运动

Progress on the role of Kalirin-7 in exercise intervention-mediated improvement of neurodegenerative diseases 

YU Meng-Yuan, TIAN Zhen-Jun^*

Institute of Sports and Exercise Biology, Shaanxi Normal University, Xi’an 710119, China

Abstract

Guanine nucleotide exchange factor Kalirin-7 (Kal-7) is a key factor in synaptic plasticity and plays an important regulatory role in the brain. Abnormal synaptic function leads to the weakening of cognitive functions such as learning and memory, accompanied by abnormal expression of Kal-7, which in turn induces a variety of neurodegenerative diseases. Exercise can upregulate the expression of Kal-7 in related brain regions to alleviate neurodegenerative diseases. By reviewing the literature on Kal-7 and neurodegenerative diseases, as well as the research progress of exercise intervention, this paper summarizes the role and possible mechanism of Kal-7 in the improvement of neurodegenerative diseases by exercise and provides a new rationale for the basic and clinical research on the prevention and treatment of neurodegenerative diseases by exercise. 

Key words: Kalirin-7 (Kal-7); neurodegenerative diseases; synaptic plasticity; exercise

收稿日期：　　录用日期：

通讯作者：田振军　　E-mail: tianzhj@snnu.edu.cn

DOI: 10.13294/j.aps.2023.0069

引用本文：

余梦苑, 田振军. Kalirin-7在运动改善神经退行性疾病中的作用研究进展[J]. 生理学报 2023; 75 (5): 659-670.

YU Meng-Yuan, TIAN Zhen-Jun. Progress on the role of Kalirin-7 in exercise intervention-mediated improvement of neurodegenerative diseases . Acta Physiol Sin 2023; 75 (5): 659-670 (in Chinese with English abstract).