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电针对放射性脑损伤作用及机制研究进展

武鑫, 李炎辉, 高剑峰^*

河南中医药大学医学院生理学学科，郑州 450046

摘要

放射性脑损伤是颅脑放射治疗后严重的并发症，影响患者的生存质量和生存期。已有大量研究表明神经元凋亡、血脑屏障损伤、突触功能受损等多种机制可能与放射性脑损伤相关。我国传统中医药在各类脑损伤治疗方面具有一定的优势，而针刺干预在临床各类脑损伤康复治疗方面具有重要的作用。电针作为一种新针刺疗法，具有可控性强、刺激均匀持久等特点，并在临床上广泛使用。本文就电针对放射性脑损伤的作用和机制进行了综述，以期为临床合理应用电针提供理论依据和实验支持。

关键词： 放射性脑损伤; 电针; 神经干细胞; 学习记忆; 突触可塑性

Research progress on the effects and mechanisms of electroacupuncture on radiation- induced brain injury

WU Xin, LI Yan-Hui, GAO Jian-Feng^*

Department of Physiology, School of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China

Abstract

Radiation-induced brain injury is a serious complication after cranio-cerebral radiotherapy, which affects the patient’s quality of life and survival. A large number of studies have shown that various mechanisms such as neuronal apoptosis, blood-brain barrier damage, and synaptic dysfunction may be related to radiation-induced brain injury. Acupuncture has an important role in clinical rehabilitation of various brain injuries. As a new type of acupuncture, electroacupuncture has the characteristics of strong control ability, uniform and long-lasting stimulation, and is widely used in clinic. This article reviews the effects and mechanisms of electroacupuncture on radiation-induced brain injury, in order to provide a theoretical basis and experimental support for reasonable clinical application.

Key words: radiation-induced brain injury; electroacupuncture; neural stem cells; learning and memory; synaptic plasticity

收稿日期：　　录用日期：

通讯作者：高剑峰　　E-mail:

DOI: 10.13294/j.aps.2023.0001

引用本文：

武鑫, 李炎辉, 高剑峰. 电针对放射性脑损伤作用及机制研究进展[J]. 生理学报 2023; 75 (1): 108-114.

WU Xin, LI Yan-Hui, GAO Jian-Feng. Research progress on the effects and mechanisms of electroacupuncture on radiation- induced brain injury. Acta Physiol Sin 2023; 75 (1): 108-114 (in Chinese with English abstract).