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硫化氢在血管钙化中作用及机制的研究进展

马建帅¹, 陈洁², 黄辉^1,*

¹中山大学附属第八医院心内科，深圳 518033；²中山大学孙逸仙纪念医院放射肿瘤科，广州 510000

摘要

血管钙化(vascular calcification, VC)在糖尿病、慢性肾脏病、及心血管疾病等患者中是一种常见的病理过程，表现为羟基磷灰石在血管壁上沉积。硫化氢(hydrogen sulfide, H2S)是继NO和CO之后在哺乳动物中发现的第三种气体信号分子，它在心血管系统中具有抗炎、抗氧化应激等作用。近年来，人们已经认识到H2S具有抗VC的作用，补充H2S及其供体可以减轻VC。本文综述了H2S对VC起保护作用的多种证据，并强调了在VC发展过程中H2S代谢改变，及H2S对VC病理生理改变的调控机制。

关键词： 血管钙化; 硫化氢; 代谢

Role and mechanism of hydrogen sulfide in vascular calcification

MA Jian-Shuai¹, CHEN Jie², HUANG Hui^1,*

¹Department of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China；²Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510000, China

Abstract

Vascular calcification is a common pathological process in patients with diabetes, chronic kidney disease, and cardiovascular disease, manifested by the deposition of hydroxyapatite on the walls of blood vessels. Hydrogen sulfide is the third gas signal molecule found in mammals after nitric oxide and carbon monoxide, which has anti-inflammatory, antioxidant stress and other effects in the cardiovascular system. In recent years, it has been recognized that hydrogen sulfide has an anti-vascular calcification effect, and supplementation with hydrogen sulfide and its donors can alleviate vascular calcification. In this review, we discussed the various evidence of the protective effect of hydrogen sulfide on vascular calcification, and highlighted the hydrogen sulfide metabolism changes and the potential regulatory mechanisms of hydrogen sulfide on the pathophysiological changes in vascular calcification.

Key words: vascular calcification; hydrogen sulfide; metabolism

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通讯作者：黄辉　　E-mail: huanghui765@hotmail.com

引用本文：

马建帅, 陈洁, 黄辉. 硫化氢在血管钙化中作用及机制的研究进展[J]. 生理学报 2022; 74 (6): 903-912.

MA Jian-Shuai, CHEN Jie, HUANG Hui. Role and mechanism of hydrogen sulfide in vascular calcification. Acta Physiol Sin 2022; 74 (6): 903-912 (in Chinese with English abstract).