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听觉事件相关电位的非对称响应机制

赖晓菲, 闫铮, 邵力承, 段放^*

华侨大学信息科学与工程学院，厦门 361021

摘要

经典的听觉oddball范式是一种常用的诱发事件相关电位(event related potential, ERP)的实验范式。本研究通过设计双耳声强非偏侧和偏侧的经典听觉oddball范式，对比分析这两种范式下的脑电ERP的响应特点，从而探讨人脑听觉空间认知加工的机制。我们通过关注P300和失匹配负波(mismatch negativity, MMN)成分的空间侧化特点，根据脑电数据的侧化指数对它们的侧化趋势进行分析，发现在听觉声强不对称的实验条件下这两种成分都表现出右半球偏侧现象，表明人脑右半球在分析空间信息中起着重要的作用。大脑的半球侧化特性与听觉刺激的实际空间方向并不相关，而是由大脑的半球功能划分所决定。此外，实验结果提示女性在空间差异刺激下诱发的MMN成分比男性更强。

关键词： 听觉空间认知; P300; 失匹配负波; 右半球偏侧

Asymmetric response mechanism of auditory event related potentials 

LAI Xiao-Fei#, YAN Zheng, SHAO Li-Cheng, DUAN Fang^*

College of Information Science and Engineering, Huaqiao University, Xiamen 361021, China

Abstract

The classical auditory oddball paradigm is a commonly used experimental paradigm for evoking event related potentials (ERPs). The present study was aimed to explore the auditory cognitive processing mechanism of space perception of human brain. We employed an auditory oddball paradigm of binaural unbiased and biased sound intensity to compare and analyze the response characteristics of ERP. By focusing on the spatial lateralization characteristics of P300 and mismatch negativity (MMN) components, we analyzed their lateralization trends according to the laterality index. We found that both P300 and MMN components showed right-hemisphere lateralization phenomenon under the stimulation of asymmetric intensity of auditory acoustic. The results suggested that the right hemisphere of human brain played a key role in spatial information processing. The results also indicated that the hemispherical characteristics of the brain were not related to the actual spatial direction of the auditory stimulus, but were determined by the hemispherical functions of the brain. Furthermore, the results suggested that the MMN components induced by spatial differences were stronger in females than those in males.

Key words: auditory spatial cognition; P300; mismatch negativity; right-hemisphere lateralization

收稿日期：　　录用日期：

通讯作者：段放　　E-mail: nkfetsh@gmail.com

DOI: 10.13294/j.aps.2022.0027

引用本文：

赖晓菲, 闫铮, 邵力承, 段放. 听觉事件相关电位的非对称响应机制[J]. 生理学报 2022; 74 (4): 563-573.

LAI Xiao-Fei#, YAN Zheng, SHAO Li-Cheng, DUAN Fang. Asymmetric response mechanism of auditory event related potentials . Acta Physiol Sin 2022; 74 (4): 563-573 (in Chinese with English abstract).