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组蛋白甲基化与糖尿病心肌病

洪浩, 李雨濛, 孟祥民, 邓天, 朱冰梅^*

四川大学华西医院再生医学研究中心，成都 610041

摘要

组蛋白甲基化是一种非常关键的翻译后修饰，在包括糖尿病心肌病在内的各种心脏病中发挥着重要作用。大量的证据显示，组蛋白甲基化修饰与高糖血症、胰岛素抵抗、脂质与晚期糖基化终末产物沉积、炎症免疫和氧化应激、内质网应激、自噬与细胞凋亡等密切相关，而这些病理因素在糖尿心肌病的发病进程中扮演着重要的角色。本文就组蛋白甲基化修饰与糖尿心肌病发病机制进行详细的探讨和阐述，以期从表观遗传学角度为糖尿病心肌病的治疗提供新的理论依据和靶点。

关键词： 表观遗传学; 组蛋白甲基化; 糖尿病心肌病

Histone methylation and diabetic cardiomyopathy

HONG Hao, LI Yu-Meng, MENG Xiang-Min, DENG Tian, ZHU Bing-Mei^*

Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract

Histone methylation is one of the key post-translational modifications that plays a critical role in various heart diseases, including diabetic cardiomyopathy. A great deal of evidence has shown that histone methylation is closely related to hyperglycemia, insulin resistance, lipid and advanced glycation end products deposition, inflammatory and oxidative stress, endoplasmic reticulum stress and cell apoptosis, and these pathological factors play an important role in the pathogenesis of diabetic cardiomyopathy. In order to provide a novel theoretical basis and potential targets for the treatment of diabetic cardiomyopathy from the perspective of epigenetics, this review discussed and elucidated the association between histone methylation and the pathogenesis of diabetic cardiomyopathy in details.

Key words: epigenetics; histone methylation; diabetic cardiomyopathy

收稿日期：　　录用日期：

通讯作者：朱冰梅　　E-mail: zhubm64@hotmail.com

DOI: 10.13294/j.aps.2022.0045

引用本文：

洪浩, 李雨濛, 孟祥民, 邓天, 朱冰梅. 组蛋白甲基化与糖尿病心肌病[J]. 生理学报 2022; 74 (3): 461-468.

HONG Hao, LI Yu-Meng, MENG Xiang-Min, DENG Tian, ZHU Bing-Mei. Histone methylation and diabetic cardiomyopathy. Acta Physiol Sin 2022; 74 (3): 461-468 (in Chinese with English abstract).