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调控性细胞死亡在肾脏缺血再灌注损伤中的研究进展

刘昕蓓, 刘文静^*

云南大学医学院，昆明 650091

摘要

肾脏上皮细胞死亡是肾脏缺血再灌注损伤引起的一种明显的病理现象，而最新研究发现调控性细胞死亡在肾脏缺血再灌注损伤中发挥着重要作用。本文就程序性坏死、铁死亡和细胞焦亡等调控性细胞死亡的相关通路、调节剂和相互作用以及在肾脏缺血再灌注损伤中的作用进行综述，以期对肾脏缺血再灌注损伤的预防和治疗提供理论基础。

关键词： 肾脏缺血再灌注损伤; 调控性细胞死亡; 程序性坏死; 铁死亡; 细胞焦亡

The role of regulated cell death in renal ischemia-reperfusion injury

LIU Xin-Bei, LIU Wen-Jing^*

School of Medicine, Yunnan University, Kunming 650091, China

Abstract

Renal ischemia-reperfusion injury (IRI) is histologically characterized by tubular cell death. Diverse pathways of regulated cell death (RCD) have been reported to contribute to renal IRI in recent studies. In this review, we discuss the signaling pathways, regulators and crosstalk of RCD, including necroptosis, ferroptosis and pyroptosis, and their role in renal IRI in order to pave the way for new therapeutic opportunities.

Key words: renal ischemia-reperfusion injury; regulated cell death; necroptosis; ferroptosis; pyroptosis

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通讯作者：刘文静　　E-mail: liuwenjing@ynu.edu.cn

DOI: 10.13294/j.aps.2022.0025

引用本文：

刘昕蓓, 刘文静. 调控性细胞死亡在肾脏缺血再灌注损伤中的研究进展[J]. 生理学报 2022; 74 (2): 320-332.

LIU Xin-Bei, LIU Wen-Jing. The role of regulated cell death in renal ischemia-reperfusion injury. Acta Physiol Sin 2022; 74 (2): 320-332 (in Chinese with English abstract).